Characterization of the Elasticity of Small Objects Buried in Media Based on the Measurements of Photoacoustic Temporal Waveforms
Characterization of the Elasticity of Small Objects Buried in Media Based on the Measurements of Photoacoustic Temporal Waveforms
复制标题
DOI：
10.2116/analsci.20p076
复制
发表时间：
2020-08
影响因子：
1.6
通讯作者：
Ayaka Naka;Toshinori Morisaku;S. Urashima;Hiroharu Yui
中科院分区：
文献类型：
--
作者：
Ayaka Naka;Toshinori Morisaku;S. Urashima;Hiroharu Yui
由于生物组织的弹性与其病理状态相关，因此在医学领域中期望开发允许弹性的非侵入性测量的新方法。我们提出了一个表征的弹性埋在介质中的物体的光声信号的时间波形。随着物体杨氏模量的增加，由波形傅里叶变换得到的功率谱的重心对应的频率增加。在我们的实验配置中，埋地物体的弹性能够从频率中识别高达约1MPa的杨氏模量。这些结果表明，光声信号的时间波形和由此产生的功率谱的测量将提供一个有用的方法，用于评估的弹性，位于深层的微观病理病变，如0或1期乳腺癌，这是很难通过传统的超声弹性成像。
Since the elasticity of biological tissues is related to their pathological states, the development of new methods allowing for non-invasive measurements of the elasticity has been desired in the medical field. We present a characterization of the elasticity of objects buried in media from the temporal waveforms of photoacoustic signals. As the increment in Young’s moduli of the objects, the frequency corresponding to the gravitational center of the power spectra obtained by the Fourier-transformation of the waveforms is increased. In our experiment configuration, the elasticity of buried objects is able to be identified up to about 1 MPa of Young’s modulus from the frequency. These results suggest that measurements on the temporal waveforms of photoacoustic signals and the resultant power spectra would provide a useful method for evaluating the elasticity of deeply-situated microscopic pathological lesions, such as stage 0 or 1 mammary gland cancer, which is difficult by conventional ultrasound elastography.