Clinicopathological and prognostic significance of platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma.
Clinicopathological and prognostic significance of platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma.
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DOI：
10.18632/oncotarget.13244
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发表时间：
2016-12-06
期刊：
影响因子：
--
通讯作者：
Zou SB
中科院分区：
文献类型：
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作者：
Song W;Wang K;Zhong FP;Fan YW;Peng L;Zou SB
据报道，血小板/淋巴细胞比率(PLR)是多种恶性肿瘤的预后因素。本研究的目的是评估其在肝细胞癌中的预后价值。我们对相关研究的电子数据库进行了全面搜索。总共有11项研究，包括2,507名患者。PLR升高与总生存率差(HR=1.78；95%CI=1.36~2.34；P<0.001)和无病/无复发生存率(HR=1.82；95%CI=1.56~2.13；P<；0.001)显著相关。大多数分组分析的结果与总体分析的结果一致。此外，高PLR与肿瘤大小<3 cm、TNM分期、淋巴结转移、远处转移和血管侵犯有关。因此，我们得出结论，治疗前PLR升高可能预示着肝细胞癌患者预后不良。
The platelet-to-lymphocyte ratio (PLR) is reported to be a prognostic factor in multiple malignancies. The aim of this study was to assess its prognostic value in hepatocellular carcinoma (HCC). We performed comprehensive searches of electronic databases for relevant studies. A total of eleven studies comprising 2,507 patients were included. Elevated PLR was significantly associated with poor overall survival (OS) (HR = 1.78; 95% CI = 1.36-2.34; P < 0.001) and disease-free survival (DFS)/recurrence-free survival (RFS) (HR = 1.82; 95% CI = 1.56-2.13; P < 0.001). The findings from most subgroup analyses were consistent with those from the overall analysis. In addition, a high PLR correlated with tumor size > 3 cm, TNM stage, lymph node metastasis, distant metastasis, and vascular invasion. We therefore conclude that elevated pretreatment PLR may be predicative of a poor prognosis in patients with HCC.