Negative affect and voluntary alcohol consumption in Wistar-Kyoto (WKY) and Sprague-Dawley rats
Negative affect and voluntary alcohol consumption in Wistar-Kyoto (WKY) and Sprague-Dawley rats
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DOI：
10.1016/s0031-9384(99)00054-2
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发表时间：
1999-08-15
影响因子：
2.9
通讯作者：
Kluczynski, J
中科院分区：
文献类型：
--
作者：
Paré, AMT;Paré, WP;Kluczynski, J
基于 Wistar-Kyoto (WKY) 大鼠品系代表抑郁行为动物模型的假设，通过三个实验研究了抑郁症与饮酒之间的所谓关系。当在 7% 酒精溶液和自来水之间进行选择时，WKY 大鼠比 Sprague-Dawley (S-D) 大鼠消耗更多的酒精。随后，在摄入酒精的 WKY 大鼠中，应激性胃溃疡的严重程度显着减轻。在实验 2 中，WKY 和 S-D 大鼠被分配接受酒精治疗或仅喝水治疗 27 天，随后在旷场测试 (OFT) 和高架十字迷宫 (EPM) 中进行观察。 WKY 大鼠摄入酒精可减少 OFT 的反应潜伏期，并增加张开手臂的时间百分比以及 EPM 中手臂进入的总数。在实验 3 中，抗抑郁药丙咪嗪降低了两种品系大鼠的饮酒量，并显着增加了 WKY 大鼠 EPM 张开臂的时间百分比。这些研究支持抑郁症和饮酒可能相关的假设。 (C) 1999 爱思唯尔科学公司。
Based on the assumption that the Wistar-Kyoto (WKY) rat strain represents an animal model for depressive behavior, the purported relationship between depression and alcohol consumption was investigated in three experiments. WKY rats consumed more alcohol than Sprague-Dawley (S-D) rats when offered a choice between a 7% alcohol solution and tap water. Subsequently, the severity of stress-induced stomach ulcers was significantly less in WKY rats that had access to alcohol. In Experiment 2, WKY and S-D rats were assigned to either an alcohol access treatment or to a water-only treatment for 27 days and subsequently observed in the open-field test (OFT) and the elevated plus-maze (EPM). Access to alcohol reduced response latency in the OFT, and increased the percent time in the open arm and the total number of arm entries in the EPM for WKY rats. In Experiment 3, the antidepressant, imipramine, reduced alcohol consumption in both strains and significantly increased percent time in the open arms of the EPM for WKY rats. These studies support the assumption that depression and alcohol consumption may be related. (C) 1999 Elsevier Science Inc.