Serum deoxyribonuclease I activity can be a useful diagnostic marker for the early diagnosis of unstable angina pectoris or non-ST-segment elevation myocardial infarction
Serum deoxyribonuclease I activity can be a useful diagnostic marker for the early diagnosis of unstable angina pectoris or non-ST-segment elevation myocardial infarction
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DOI：
10.1016/j.jjcc.2012.01.005
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发表时间：
2012-05-01
影响因子：
2.5
通讯作者：
Yasuda, Toshihiro
中科院分区：
文献类型：
--
作者：
Fujibayashi, Kousuke;Kawai, Yasuyuki;Yasuda, Toshihiro
背景和目的：近年来，血清脱氧核糖核酸酶I(DNase I)活性已成为短暂性心肌缺血的潜在诊断指标。为了评价血清DNase I活性能否作为诊断不稳定型心绞痛(UAP)或非ST段抬高心肌梗死(NSTEMI)的有用生物标志物，我们观察了UAP和NSTEMI患者胸痛后DNase I水平的动态变化。方法和结果：33例患者分为UAP/NSTEMI组和胸痛综合征组(CPS组)。UAP/NSTEMI患者胸痛后3h内血清DNase I活性水平及入院至入院后3h血清DNase I活性百分比差值的绝对中位值均显著高于CPS患者。我们对患者进行评估，如果血清水平或百分比差异超过相应的临界值，则显示DNase I活性阳性结果。在心肌肌钙蛋白T和肌酸激酶MB同工酶无升高的UAP/NSTEMI患者中，胸痛后6h内检测DNase I的敏感性和特异性分别为89%和88%。结论：无论有无心肌损害的证据，血清DNase I活性均可作为胸痛后UAP/NSTEMI早期诊断的有用指标。(C)2012年日本心脏病学院。爱思唯尔有限公司出版。保留所有权利。
Background and purpose: Recently, serum deoxyribonuclease I (DNase I) activity has been highlighted as a potential diagnostic marker for transient myocardial ischemia. To evaluate whether serum DNase I activity can be a useful biomarker for diagnosing unstable angina pectoris (UAP) or non-ST-segment elevation myocardial infarction (NSTEMI), we investigated serial changes in DNase I levels after chest pain in UAP and NSTEMI (UAP/NSTEMI) patients.Methods and results: Thirty-three and ten patients classified into the UAP/NSTEMI and the chest pain syndrome (CPS) group, respectively, were enrolled. The serum DNase I activity levels within 3 h after chest pain and the absolute median value of percentage differences in serum DNase I activity levels from admission to 3h after hospitalization in the UAP/NSTEMI patients was significantly higher than those in the CPS patients. We evaluated the patients to show positive results for DNase I activity if the serum levels or percentage differences exceeded the corresponding cut-off values. The sensitivity and specificity of DNase I within 6h after chest pain in the UAP/NSTEMI patients without elevated levels of cardiac troponin T and the MB isoenzyme of creatine kinase were 89% and 88%, respectively.Conclusions: Serum DNase I activity can be a useful marker for the early diagnosis of UAP/NSTEMI after the onset of chest pain, irrespective of the evidence of myocardial injury. (C) 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.