REGIONAL SPINAL-CORD BLOOD-FLOW IN RATS AFTER SEVERE CORD TRAUMA
REGIONAL SPINAL-CORD BLOOD-FLOW IN RATS AFTER SEVERE CORD TRAUMA
复制标题
DOI：
10.3171/jns.1978.49.6.0844
复制
发表时间：
1978-01-01
影响因子：
4.1
通讯作者：
TATOR, CH
中科院分区：
文献类型：
--
作者：
RIVLIN, AS;TATOR, CH
在硬膜外夹压迫技术造成急性脊髓损伤后，测量了 12 只白化大鼠的脊髓血流量 (SCBF)。夹子以 180 g 的力压缩脐带 5 分钟，造成严重损伤，此前已显示这种损伤会导致严重的功能缺陷。损伤后15分钟、2小时和24小时通过14C-安替比林放射自显影技术和扫描显微镜光度计测量局部SCBF。在 15 分钟和 2 小时时，白质和灰质血流量严重减少，而在 24 小时时，只有很小的改善。在距脊髓损伤部位近端和远端相当远的地方，白质和灰质中可见血流局部减少。该模型表明，严重的脊髓压迫损伤会导致脊髓发生严重的创伤后缺血，并持续至少 24 小时。
Spinal cord blood flow (SCBF) was measured in 12 albino rats following acute cord injury produced by the extradural clip compression technique. Severe injury was produced with the clip compressing the cord with a force of 180 g for 5 min, an injury previously shown to produce a severe functional deficit. Regional SCBF was measured 15 min, 2 h and 24 h after injury by the 14C-antipyrine autoradiographic technique and a scanning microscope photometer. At 15 min and 2 h, white and gray matter blood flow was severely diminished, and, at 24 h, there was only minimal improvement. Focal decreases in blood flow were seen in white and gray matter for a considerable distance proximal and distal to the site of cord trauma. This model shows that severe cord compression injury produces severe posttraumatic ischemia in the cord which lasts for at least 24 h.