Plasma total cholesterol level as a risk factor for Alzheimer disease - The Framingham study
Plasma total cholesterol level as a risk factor for Alzheimer disease - The Framingham study
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DOI：
10.1001/archinte.163.9.1053
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发表时间：
2003-05-12
影响因子：
--
通讯作者：
Wolf, PA
中科院分区：
文献类型：
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作者：
Tan, ZS;Seshadri, S;Wolf, PA
背景资料：先前的研究检查血浆胆固醇水平与阿尔茨海默病（AD）发展风险之间的关系尚未得出结论。我们研究了基线和终生血浆总胆固醇水平的影响，平均在许多年的风险AD在一个大的，人口为基础的coherent.Methods：五千二百九名受试者从Frawelling研究原始队列进行了两年一次的心血管危险因素的评估，自1950年以来，与估计的血清总胆固醇水平在19个这25个两年一次的检查。研究样本由来自该队列的1026名受试者组成，这些受试者在第20个检查周期（1988-1989年）时存活且无卒中和痴呆，并接受了载脂蛋白E（APOE）基因分型。主要结果的措施是事件AD诊断使用标准的标准，根据平均总胆固醇水平在两年一次的检查周期1至15和基线总胆固醇水平在第20个两年一次的检查cycle.Results：阿尔茨海默病的77名受试者从1992年至2000年。校正年龄、性别、APOE基因型、吸烟、体重指数后（以体重（公斤）除以身高（米）的平方计算）、冠心病和糖尿病，我们发现在两年一次的检查周期1至15中，AD发病风险与平均胆固醇水平之间没有显著关联（每升高10 mg/dL [0.3 mmol/L]的风险比，0.95; 95%置信区间，0.87-1.04）或检查时的基线总胆固醇水平20（风险比，0.97; 95%可信区间，0.90-1.05）。在这个大的，基于人群的队列中，基线和长期平均血清总胆固醇水平与AD事件的风险无关。
Background: Previous studies examining the association of plasma cholesterol levels with the risk for development of Alzheimer disease (AD) have been inconclusive. We examined the impact of baseline and lifetime plasma total cholesterol levels averaged across many years on the risk for AD in a large, population-based cohort.Methods: Five thousand two hundred nine subjects from the Framingham Study original cohort underwent biennial evaluation for cardiovascular risk factors since 1950, with estimations of serum total cholesterol levels at 19 of these 25 biennial examinations. The study sample consisted of 1026 subjects from this cohort who were alive and free of stroke and dementia at examination cycle 20 (1988-1989) and had undergone apolipoprotein E (APOE) genotyping. The main outcome measure was incident AD diagnosed using standard criteria,according to average total cholesterol levels across biennial examination cycles 1 to 15 and baseline total cholesterol level measured at the 20th biennial examination cycle.Results: Alzheimer disease developed in 77 subjects from 1992 to 2000. After adjustment for age, sex, APOE genotype, smoking, body mass index (calculated as weight in kilograms divided by the square of height in meters), coronary heart disease, and diabetes, we found no significant association between the risk for incident AD and average cholesterol level at biennial examination cycles 1 to 15 (hazard ratio per 10-mg/dL [0.3-mmol/L] rise, 0.95; 95% confidence interval, 0.87-1.04) or baseline total cholesterol level at examination 20 (hazard ratio, 0.97; 95% confidence interval, 0.90-1.05).Conclusion: In this large, population-based cohort, baseline and long-term average serum total cholesterol levels were not associated with the risk for incident AD.