Validity of parental-reported questionnaire data on Danish children's use of asthma-drugs: A comparison with a population-based prescription database
Validity of parental-reported questionnaire data on Danish children's use of asthma-drugs: A comparison with a population-based prescription database
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DOI：
10.1007/s10654-004-1501-6
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发表时间：
2005-01-01
影响因子：
13.6
通讯作者：
Sorensen, HT
中科院分区：
文献类型：
--
作者：
Wogelius, P;Poulsen, S;Sorensen, HT
这项研究的目的是检验基于问卷的父母对丹麦儿童使用哮喘药物的报告的有效性--估计为敏感性、特异性和预测值。在一项关于哮喘和牙科焦虑之间关系的基于人群的横断面研究中，我们将父母对他们孩子在过去12个月中使用哮喘药物的回答与国家医疗服务(NHS)的数据进行了比较，这些数据来自处方数据库，其中包括吸入的β2-激动剂和/或吸入皮质类固醇的处方，在张贴父母调查问卷的日期之前的14个月内。2001年，在丹麦北日德兰县的四个市镇，1273名6至8岁儿童的父母完成了问卷调查。在使用频率方面，当答案“每天”、“经常”和“有时”组合时，敏感度从57.9%(95%可信区间：47.8-67.3%)增加到91.6%(95%可信区间：84.3-95.7%)。所有答案的特异度均超过95.9%(95%CI：94.6~96.9%)。将“每天”、“经常”和“有时”三个答案结合起来，阳性预测值从64.4%(95%CI：56.1~72.0%)增加到94.8%(95%CI：85.9~98.2%)。所有答案的阴性预测值(NPV)均超过96.7%(95%CI：95.5-97.6%)。基于问卷的父母对儿童一年哮喘药物使用情况的报告在流行病学研究中似乎是有效的，这取决于研究的问题和设计。
The aim of this study was to examine the validity - estimated as the sensitivity, specificity, and predictive values - of questionnaire-based parental reporting on Danish children's use of asthma drugs. Within a population-based cross-sectional study on the association between asthma and dental anxiety, we compared parental answers on their children's use of asthma drugs during the past 12 months with National Health Service (NHS) data from a prescription database on prescriptions of inhaled beta 2-agonists, inhaled corticosteroids, or both for a period of 14 months preceding the date of posting the parental questionnaires. In four municipalities in North Jutland County, Denmark, in 2001, parents of 1273 children between the ages of 6 and 8 years completed the questionnaire. For frequency of use, the sensitivity increased from 57.9% (95% confidence interval [CI]: 47.8-67.3%) for the answer 'Every day' to 91.6% (95% CI: 84.3-95.7%) when the answers 'Every day', 'Often', and 'Sometimes' were combined. The specificity exceeded 95.9% (95% CI: 94.6-96.9%) for all answers. The positive predictive value (PPV) increased from 64.4% (95% CI: 56.1-72.0%) when the answers 'Every day', 'Often', and 'Sometimes' were combined to 94.8% (95% CI: 85.9-98.2%) for the answer 'Every day'. The negative predictive value (NPV) both exceeded 96.7% (95% CI: 95.5-97.6%) for all answers. Questionnaire-based parental reporting on children's one-year asthma-drug use appears to be valid in epidemiological research depending on the study question and design.