High fever-related maternal diseases as possible causes of multiple congenital abnormalities: A population-based case-control study
High fever-related maternal diseases as possible causes of multiple congenital abnormalities: A population-based case-control study
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DOI：
10.1002/bdra.20369
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发表时间：
2007-07-01
影响因子：
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通讯作者：
Banhidy, Ferenc
中科院分区：
文献类型：
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作者：
Czeizel, Andrew E.;Puho, Erzsebet H.;Banhidy, Ferenc
背景：多发性先天性畸形(MCAS)是最严重的结构性出生缺陷，因此，我们决定评估MCAS可能的病因。方法：对匈牙利先天畸形病例对照监测(1980-1996)以人群为基础的大数据集进行评价。结果：我们比较了1,349例MCAS患者、2,405例没有任何缺陷的匹配人群对照和21,494例有孤立先天异常的畸形对照的数据。高热相关流感、普通感冒继发并发症、扁桃体炎和复发性口腔面部疱疹与MCAS的高风险相关(调整OR值95%CLS：2.3，1.8-2.9)。然而，退热药物治疗降低了MCAS的风险(调整后的OR为95%CI：1.6，0.9~2.9)。结论：高热相关的母体疾病与MCAS的高风险之间存在关联；然而，这些MCAS中的某些部分是可以通过退热治疗来预防的。
Background: Multiple congenital abnormalities (MCAs) represent the most severe category of structural birth defects; therefore, we decided to evaluate the possible etiological factors for MCAs. Methods: The population-based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (1980-1996) was evaluated. Results: We compared the data of 1,349 cases with MCAs, 2,405 matched population controls without any defect, and 21,494 malformed controls with isolated congenital abnormalities. An association was found between a higher risk for MCAs and high fever-related influenza, common cold with secondary complications, tonsillitis, and recurrent orofacial herpes (adjusted ORs with 95% Cls: 2.3, 1.8-2.9). However, the risk for MCAs was reduced by antifever drug therapy (adjusted OR with 95% CI: 1.6, 0.9-2.9). Conclusions: An association was found between high fever-related maternal diseases and a higher risk for MCAs; however, a certain portion of these MCAs is preventable by antifever therapy.