Electrospun Upconversion Composite Fibers as Dual Drugs Delivery System with Individual Release Properties
Electrospun Upconversion Composite Fibers as Dual Drugs Delivery System with Individual Release Properties
复制标题
静电纺丝上转换复合纤维作为具有单独释放特性的双重药物输送系统
DOI：
10.1021/la402080y
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发表时间：
2013-07-30
期刊：
影响因子：
3.9
通讯作者：
Lin, Jun
中科院分区：
文献类型：
--
作者：
Hou, Zhiyao;Li, Xuejiao;Lin, Jun
设计并制备了新型多功能聚己内酯-明胶包裹上转换核/壳纳米二氧化硅(NPs)复合纤维作为双给药系统(DDDS)，分别释放吲哚美辛(IMC)和阿霉素(DOX)。用介孔二氧化硅壳层包裹均匀的、单分散的上转换发光材料NaYF4：Yb3+，Er3+纳米晶(UCNCs)，形成核/壳结构的NaYF4：Yb3+，Er3+@mSiO(2)(UCNCs@mSiO(2))纳米颗粒，作为DOX的载体。将这些负载DOX的UCNCs@mSiO(2)纳米粒子分散到聚己内酯(PCL)和含有IMC的明胶基电纺液的混合物中，然后通过静电纺丝方法制备双载药复合纤维(DDD)。测试了DDDS的药物释放曲线，结果表明，从电纺复合纤维中释放的IMC和DOX具有明显的性质。IMC在复合纤维中呈快速释放，而DOX在复合纤维中呈缓释行为。此外，H-2(11/2)/S-4(3/2)-I-4(15/2)和F-4(9/2)-I-4(15/2)的UC发光强度比随体系中DOX含量的不同而不同，因此可以通过发光共振能量转移(LRET)机制来跟踪和监测药物的释放。
Novel multifunctional poly(epsilon-caprolactone)-gelatin encapsulating upconversion core/shell silica nanoparticles (NPs) composite fibers as dual drugs delivery system (DDDS), with indomethacin (IMC) and doxorubicin (DOX) releasing in individual release properties, have been designed and fabricated via electrospinning process. Uniform and monodisperse upconversion (UC) luminescent NaYF4:Yb3+, Er3+ nanocrystals (UCNCs) were encapsulated with mesoporous silica shells, resulting in the formation of core/shell structured NaYF4:Yb3+, Er3+@mSiO(2) (UCNCs@mSiO(2)) NPs, which can be performed as DOX delivery carriers. These UCNCs@mSiO(2) NPs loading DOX then were dispersed into the mixture of poly(epsilon-caprolactone) (PCL) and gelatin-based electrospinning solution containing IMC, followed by the preparation of dual drug-loaded composite fibers (DDDS) via electrospinning method. The drugs release profiles of the DDDS were measured, and the results indicated that the IMC and DOX released from the electrospun composite fibers showed distinct properties. The IMC in the composite fibers presented a fast release manner, while DOX showed a sustained release behavior. Moreover, the UC luminescent intensity ratios of H-2(11/2)/S-4(3/2)-I-4(15/2) to F-4(9/2)-I-4(15/2) from Er3+ vary with the amounts of DOX in the system, and thus drug release can be tracked and monitored by the luminescence resonance energy transfer (LRET) mechanism.