Pneumococcal vaccine coverage among individuals aged 18 to 64 years old with underlying medical conditions in the UK: a retrospective database analysis.
Pneumococcal vaccine coverage among individuals aged 18 to 64 years old with underlying medical conditions in the UK: a retrospective database analysis.
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DOI：
10.1186/s12889-020-09613-5
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发表时间：
2020-10-21
影响因子：
4.5
通讯作者：
Nozad B
中科院分区：
文献类型：
--
作者：
Matthews I;Lu X;Xia Q;Black W;Nozad B
在英国，某些有预处理条件的群体有资格接种肺炎球菌多糖疫苗(PPV23)。这些人已经10 年没有接种疫苗的报告了。因此，这项研究调查了18- 岁且有某些潜在医疗条件的个人的肺炎球菌疫苗接种率、自确诊以来接种疫苗的时间以及与接种疫苗相关的因素。使用临床实践研究数据链(CPRD)进行了回溯性数据库分析。在索引日期(2011年1月1日至2015年12月31日)被诊断为潜在疾病的18岁至 岁的个人包括在这项研究中。使用读码识别潜在疾病和肺炎球菌疫苗接种。使用多变量Logistic回归模型确定与肺炎球菌疫苗接种相关的因素。共有99,153名有潜在疾病的个人被纳入这项研究。随访1年内，13.6%接种过肺炎链球菌苗。经过4年的随访，这一数字上升到32.0%。在整个队列中，从诊断到接种疫苗的平均时间为148.7 天。根据多因素分析结果，慢性心脏病、慢性肾脏疾病、慢性肝病、慢性呼吸系统疾病或糖尿病患者接种疫苗的可能性显著低于免疫抑制患者(P <； 0.0001)。如果个人在第一年的随访中接受了流感疫苗接种，那么他们接受肺炎球菌疫苗接种的可能性比没有接受疫苗的人要高得多(P <； 0.001)。尽管疫苗接种和免疫联合委员会(JCVI)建议在临床风险群体中接种肺炎球菌疫苗，但在英国，对于18岁至且有潜在健康状况的个人，肺炎球菌疫苗的接种率并不理想。应进一步强调扩大英国肺炎球菌疫苗接种覆盖面的重要性，因为与指示性潜在医疗状况相关的发病率和死亡率风险增加。
In the UK certain groups with pre-disposing conditions are eligible for vaccination with the pneumococcal polysaccharide vaccine (PPV23). Uptake of the vaccine in these individuals has not been reported for 10 years. Hence this study investigated the rates of pneumococcal vaccination, the time to vaccination since diagnosis, and factors associated with vaccination in individuals aged 18–64 years with certain underlying medical conditions. A retrospective database analysis was conducted using the Clinical Practice Research Datalink (CPRD). Individuals aged 18 to 64 years who had a diagnosis for underlying medical conditions of interest at the index date (January 1, 2011 to December 31, 2015) were included in this study. Both underlying conditions and pneumococcal vaccination were identified using Read codes. A multivariable logistic regression model was used to identify factors associated with pneumococcal vaccination. A total of 99,153 individuals with underlying medical conditions were included in this study. Within 1 year of follow-up, 13.6% had received pneumococcal vaccination. This figure rose to 32.0% after 4 years of follow-up. The mean time between diagnosis and vaccination was 148.7 days across the overall cohort. Based on multivariate analysis of results, individuals with chronic heart disease, chronic kidney disease, chronic liver disease, chronic respiratory disease or diabetes mellitus were significantly less likely (P < 0.0001) to be vaccinated than those with immunosuppression. Individuals were significantly more likely to receive a pneumococcal vaccination if they received an influenza vaccination in the first year of follow-up than those who did not (P < 0.001). Despite the Joint Committee on Vaccination and Immunisation (JCVI) recommendations for pneumococcal vaccination in clinical risk groups, rates of pneumococcal vaccination are suboptimal in the UK for individuals aged 18–64 with underlying medical conditions. Further emphasis should be made on the importance of increased pneumococcal vaccination coverage in the UK, given the increased risk of morbidity and mortality associated with indicative underlying medical conditions.
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影响因子：
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通讯作者：
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影响因子：
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