CNTRICS Imaging Biomarker Selections: Executive Control Paradigms
CNTRICS Imaging Biomarker Selections: Executive Control Paradigms
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DOI：
10.1093/schbul/sbr114
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发表时间：
2012-01-01
影响因子：
6.6
通讯作者：
Macdonald, Angus, III
中科院分区：
文献类型：
--
作者：
Carter, Cameron S.;Minzenberg, Michael;Macdonald, Angus, III
在本文中，我们描述了第五届提高精神分裂症认知的认知神经科学治疗研究会议的结果，该会议确定了候选成像生物标志物，用于测量与特定认知过程相关的神经活动，这些神经活动针对精神分裂症和其他疾病的治疗开发。本手稿描述了选择与执行控制相关的措施的过程，以及建议进一步发展的具体措施。建议使用两种范式来测量执行控制、规则生成和选择以及控制动态调整这两个核心组成过程背后的认知和神经机制。这两个范例是 AX 连续性能任务任务（字母和点形式），作为功能性磁共振成像 (fMRI) 范例实现，以参与支持规则生成和选择的神经系统；以及切换 Stroop 任务，作为 fMRI 或脑电图实现，可用作规则生成和选择以及控制动态调整的度量。提供了每个范式的详细描述，以及对其认知和神经有效性以及测量特性相关文献的回顾。建议进一步开发这两种范式，包括在认知和神经水平上进一步验证以及在受试者耐受性、心理测量和神经测量特征方面进行优化。
In this article, we describe results of the 5th Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia meeting which identified candidate imaging biomarkers for used in measuring neural activity associated with specific component processes of cognition that are targeted for treatment development in schizophrenia and other disorders. This manuscript describes the process by which measures related to executive control were selected, along with the specific measures recommended for further development. Two paradigms were recommended for measurement of the cognitive and neural mechanisms underlying 2 core component processes of executive control, rule generation and selection, and dynamic adjustments of Control. The 2 paradigms are the AX continuous performance task task (letter and dot forms), implemented as an functional magnetic resonance imaging (fMRI) paradigm to engage neural systems supporting rule generation and selection, and the switching Stroop task, implemented as either fMRI or electroencephalography that may be used as a measure of both rule generation and selection as well as dynamic adjustment in control. A detailed description of each paradigm, together with a review of the relevant literature related to their cognitive and neural validity and measurement properties is provided. These 2 paradigms are recommended for further development, including further validation at the cognitive and neural level and optimization with respect to subject tolerability, psychometric, and neurometric features.