Low-cost embossed-paper micro-channels for spontaneous capillary flow
Low-cost embossed-paper micro-channels for spontaneous capillary flow
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DOI：
10.1016/j.snb.2017.03.144
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发表时间：
2017-09-01
影响因子：
8.4
通讯作者：
Berthier, J.
中科院分区：
文献类型：
--
作者：
Gosselin, D.;Belgacem, M. N. .;Berthier, J.
亲水性多孔基底，特别是纸，现在广泛用于微流体装置的制造。这些材料是非常有吸引力的，因为它们的低成本和它们产生毛细流动的能力。这种材料避免了外部压力源或注射泵的需要。然而，毛细流动芯吸亲水性纤维基质经历非特异性吸附并且取决于环境条件如湿度。在这篇文章中，提出了一种新的制造方法，以创建低成本的滤纸微流体器件允许自发毛细流动。因此，压印用于在防水和亲水的纸表面上设计中空的微流体通道和腔室。由于所获得的中空通道是无纤维的，因此避免了吸渗的问题。此外，纸张表面是亲水性的，压花装置中的毛细流动是自发的。因此，这种微流体装置提供了在资源贫乏的环境中进行诊断的有效支持。在这项工作中，它表明，比色葡萄糖检测可以实现使用滤纸通道。检测在12分钟内完成，无论是通过肉眼还是通过分析用智能手机相机拍摄的照片进行量化。(C)2017爱思唯尔B.V.保留所有权利。
Hydrophilic porous substrates, in particular paper, are now widely used for the fabrication of microfluidic devices. These materials are very attractive because of their low-cost and their ability to generate capillary flow. Such materials avoid the need of external pressure sources or syringe pumps. However, capillary flows wicking a hydrophilic fiber matrix experience non-specific adsorption and depend on environmental conditions such as humidity. In this article a novel fabrication method is proposed to create low-cost embossed-paper microfluidic devices allowing for spontaneous capillary flow. Thus, embossing is used to design hollow microfluidic channels and chambers on a waterproof and hydrophilic paper surface. Because the hollow-channels obtained are fiber-free, the issues of imbibition are avoided. Besides, the paper surface being hydrophilic, the capillary flow in the embossed device is spontaneous. Thus, such microfluidic devices provide an efficient support to perform diagnostics in resource-poor settings. In this work, it is shown that a colorimetric glucose detection can be achieved using embossed-paper channels. The detection is achieved in twelve minutes, either by naked eyes or by analyzing pictures taking with a smartphone camera for quantification. (C) 2017 Elsevier B.V. All rights reserved.