RTOG, CTCAE and WHO criteria for acute radiation dermatitis correlate with cutaneous blood flow measurements
RTOG, CTCAE and WHO criteria for acute radiation dermatitis correlate with cutaneous blood flow measurements
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DOI：
10.1016/j.breast.2015.01.008
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发表时间：
2015-06-01
期刊：
影响因子：
3.9
通讯作者：
Chuang, Hung-Yi
中科院分区：
文献类型：
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作者：
Huang, Chih-Jen;Hou, Ming-Feng;Chuang, Hung-Yi
背景：各种临床医生评估的评分标准已用于对急性放射性皮炎进行分级。然而，尚不清楚这些评分标准是否与放疗后客观皮肤生物物理参数的变化和患者报告的症状相关。我们试图将三种不同的临床医生评估的评分标准与接受放射治疗的乳腺癌患者的皮肤生物物理变化和患者报告的症状联系起来。方法：在大学医院医疗中心进行了一项前瞻性队列研究。使用 RTOG、CTCAE 和 WHO 临床评分标准对 101 名乳腺癌患者的急性放射性皮炎严重程度进行分级。我们还在放疗前后通过非侵入性技术测量了各种皮肤生物物理参数（皮肤血流量、色素沉着、水合作用和 pH 值）。使用问卷评估患者报告的乳房症状（疼痛、瘙痒、局部发热和紧绷）。 结果：三种不同的临床医生评估的评分标准与乳腺癌放疗后皮肤血流量的变化相关性最强（RTOG 的相关系数为 0.70，CTCAE 的相关系数为 0.68，WHO 的相关系数为 0.50）。所有三个评分标准也显示出与皮肤色素沉着变化的中度相关性（相关系数 0.4-0.5），但与皮肤水合作用或 pH 值没有显着相关性（相关系数
Background: Various clinician-assessed scoring criteria have been used to grade acute radiation dermatitis. However, it is not known whether these scoring criteria correlate with changes in objective skin biophysical parameters and patient-reported symptoms following radiotherapy. We seek to correlate three different clinician-assessed scoring criteria with skin biophysical changes and patient-reported symptoms in breast cancer patients undergoing radiotherapy.Methods: A prospective cohort study was performed in a university hospital medical center. The severity of acute radiation dermatitis in 101 breast cancer patients was graded using the RTOG, CTCAE and WHO clinical scoring criteria. We also measured various skin biophysical parameters (skin blood flow, pigmentation, hydration, and pH) by non-invasive techniques before and after radiotherapy. Patient-reported breast symptoms (pain, itching, local heat, and tightness) were evaluated using a questionnaire.Results: The three different clinician-assessed scoring criteria correlated most strongly with changes in cutaneous blood flow following radiotherapy for breast cancer (correlation coefficient 0.70 for RTOG, 0.68 for CTCAE, and 0.50 for WHO). All three scoring criteria also showed moderate correlation with changes in skin pigmentation (correlation coefficients 0.4-0.5), but showed no significant correlation with skin hydration or pH (correlation coefficients