Type-specific antibodies in children with sickle cell anemia given polyvalent pneumococcal vaccine.
Type-specific antibodies in children with sickle cell anemia given polyvalent pneumococcal vaccine.
复制标题
接受多价肺炎球菌疫苗的镰状细胞性贫血儿童的类型特异性抗体。
DOI：
10.1016/s0022-3476(82)80440-x
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Schiffman,G
中科院分区：
文献类型：
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作者：
Kaplan,J;Frost,H;Sarnaik,S;Schiffman,G
结果抗体浓度的几何平均值见表I。假设300 ng抗体N/ml为保护水平7（随后讨论），接种前针对抗原1、3、4、8、9、12和18的抗体浓度几何平均值在保护范围内，而针对抗原6A、7、14、19 F和23的抗体浓度低于该范围。如表If所示，在接种前，70%或更多的受试者具有针对PPS抗原1、3、4、8、9、12、18和23的保护性抗体水平，而这些受试者中不超过44%的受试者具有针对PPS抗原1、3、4、8、9、12、18和23的保护性抗体水平。
RESULTS The geometric means of the antibody concentrations are shown in Table I. Presuming 300 ng antibody N/ml as a protective level 7 (to be discussed subsequently), the prevaccination geometric mean antibody concentrations to antigens 1, 3, 4, 8, 9, 12, and 18 were in the protective range, whereas the concentrations of antibody to antigens 6A, 7, 14, 19F, and 23 were below this range. As shown in Table If, before vaccination, 70% or more of the test subjects had protective antibody levels to PPS antigens 1, 3, 4, 8, 9, 12, 18, and 23, whereas no more than 44% of these subjects