High-glycemic index meal acutely potentiates blood pressure response to static handgrip exercise in healthy humans.
High-glycemic index meal acutely potentiates blood pressure response to static handgrip exercise in healthy humans.
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高血糖指数膳食会急剧增强健康人对静态握力运动的血压反应。
DOI：
10.1152/japplphysiol.00703.2022
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Mizuno,Masaki
中科院分区：
文献类型：
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作者：
Kashima,Hideaki;Endo,MasakoYamaoka;Kanda,Masako;Miura,Akira;Fukuba,Yoshiyuki;Mizuno,Masaki
餐后血糖水平急剧升高，具体取决于所吃膳食的类型。然而，目前尚不清楚餐后高血糖是否暂时影响心血管对静态握力运动（SHG-ex）的反应。因此，本研究旨在探讨食用高血糖指数 (HGI) 膳食引起的血糖升高是否会影响对 SHG-ex 的升压反应。共有 14 名健康参与者（7 名女性和 7 名男性）食用 HGI 餐、低血糖指数 (LGI) 餐或不进餐（对照）。参与者在餐前和餐后 60 分钟进行 30% 最大自主收缩 SHG-ex，然后进行运动后肌肉缺血 (PEMI) 测试。测量血糖、血浆胰岛素和血浆甘油三酯水平，并计算进餐后 60 分钟 (AUC0-60 分钟) 的曲线下面积。 HGI和LGI组的血糖和胰岛素AUC0-60分钟均高于对照组（P<0.001）。餐后 60 分钟，SHG-ex 期间 HGI 组的血压变化显着大于对照组，但 LGI 组则没有。餐后60 min SHG-ex开始和结束时的血压变化与血糖AUC0-60 min（分别为r= 0.321，P= 0.038；r= 0.402，P= 0.008）和血浆胰岛素AUC0-60 min（r= 0.339，P= 0.028；r= 0.302，P= 0.052，分别）。然而，在 PEMI 期间没有观察到关联。这些数据表明，健康年轻人的餐后高血糖和高胰岛素血症会严重加剧 SHG-ex 期间的升压反应。新消息和值得注意的是，食用高血糖指数 (HGI) 膳食后出现的餐后高血糖会增强健康年轻人对静态握力运动 (SHG-ex) 的血压反应。这些发现为了解饮食对健康成年人对运动的急性循环反应的作用提供了重要的见解。
Blood glucose levels acutely increase postprandially depending on the type of meal consumed. However, it remains unclear whether postprandial hyperglycemia temporally affects cardiovascular responses to static handgrip exercise (SHG-ex). Thus, this study aimed to examine whether increased blood glucose induced by consumption of a high-glycemic index (HGI) meal affects pressor response to SHG-ex. A total of 14 healthy participants (7 women and 7 men) consumed an HGI meal, a low-glycemic index (LGI) meal, or no meal (control). Participants performed 30% maximal voluntary contraction SHG-ex followed by a postexercise muscle ischemia (PEMI) test before the meal and 60 min after consuming the meal. Blood glucose, plasma insulin, and plasma triglyceride levels were measured, and the area under the curve until 60 min (AUC0–60 min) after meal consumption was calculated. The HGI and LGI groups showed higher blood glucose and insulin AUC0–60 minthan the control group (P< 0.001). At 60 min after the meal, the changes in blood pressure during SHG-ex were significantly greater in the HGI group, but not in the LGI group, than in the control group. The changes in blood pressure at the onset and end of SHG-ex 60 min after the meal were positively correlated with blood glucose AUC0–60 min(r= 0.321,P= 0.038;r= 0.402,P= 0.008, respectively) and plasma insulin AUC0–60 min(r= 0.339,P= 0.028;r= 0.302,P= 0.052, respectively). However, no association was observed during PEMI. These data suggest that postprandial hyperglycemia and hyperinsulinemia acutely exaggerate pressor response during SHG-ex in healthy young adults.NEW & NOTEWORTHYPostprandial hyperglycemia following consumption of a high-glycemic index (HGI) meal potentiated blood pressure response to static handgrip exercise (SHG-ex) in healthy young adults. These findings provide important insight into the role of the diet on acute circulatory response to exercise in healthy adults.