Tumor promoter-stimulated protein phosphorylation in mouse epidermis is inhibited by bromophenacyl bromide.
Tumor promoter-stimulated protein phosphorylation in mouse epidermis is inhibited by bromophenacyl bromide.
复制标题
溴苯那酰溴可抑制小鼠表皮中肿瘤启动子刺激的蛋白质磷酸化。
DOI：
10.1111/1523-1747.ep12265514
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Penn,A
中科院分区：
文献类型：
--
作者：
Edinger,FM;Penn,A
内源性蛋白激酶对小鼠表皮蛋白的磷酸化和花生四烯酸的产生是由肿瘤促进剂12-O-十四烷酰基佛波醇-13-乙酸酯刺激的过程。在小鼠表皮匀浆，每个过程，以及生产的二酰基甘油（蛋白激酶C的生理激活剂），抑制溴苯甲酰甲基溴在浓度相当于那些抑制肿瘤的促进。这些结果支持了小鼠皮肤中肿瘤促进可能是由蛋白激酶C激活介导的假设。
Phosphorylation of mouse epidermal proteins by endogenous protein kinases and production of arachidonic acid are processes stimulated by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. In mouse epidermal homogenates, each process, as well as production of diacylglycerol (the physiologic activator of protein kinase C), was inhibited by bromophenacyl bromide at concentrations equivalent to those that inhibit tumor promotion. These results lend support to the hypothesis that tumor promotion in mouse skin may be mediated by activation of protein kinase C.