Long-term high air pollution exposure induced metabolic adaptations in traffic policemen.
Long-term high air pollution exposure induced metabolic adaptations in traffic policemen.
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DOI：
10.1016/j.etap.2018.01.002
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发表时间：
2018-03
影响因子：
4.3
通讯作者：
Chaochao Tan;Yupeng Wang;Mingyue Lin;Zhu Wang;Li He;Zhiyi Li;Y. Li;Keqian Xu
中科院分区：
文献类型：
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作者：
Chaochao Tan;Yupeng Wang;Mingyue Lin;Zhu Wang;Li He;Zhiyi Li;Y. Li;Keqian Xu
目的探讨长期暴露于PM2.5环境中对交通警察的不良生理影响。方法选择交通警察183名和机关警察88名作为对照组。获得了交警和机关民警工作场所的PM2.5浓度。详细的个人问卷调查和常规实验室检查，包括血液学，空腹血糖，血脂，肝，肾，免疫和肿瘤相关的标志物进行了本study.ResultsA的FBG，HDL-C和CEA值和PM2.5暴露时间之间的剂量反应关系进行了观察。多变量分析证实，每天在户外值班一小时，持续一年，与FBG增加0.005%相关（95% CI：0.0004%至0.009%），CEA为0.012%（95% CI：0.006%-0.017%），HDL-C降低0.001%结论长期高浓度大气污染暴露可能导致代谢适应，并可能参与心血管疾病和糖尿病的发生。
ObjectiveTo assess the adverse physiological changes induced by long-term exposure to PM2.5.MethodsTotally 183 traffic policemen and 88 office policemen as the control group, were enrolled in this study. The concentrations of PM2.5 in both the working places of traffic and office policemen were obtained. Detailed personal questionnaires and conventional laboratory tests including hematology, fasting blood glucose, blood lipids, liver, kidney, immunity and tumor-related markers were conducted on all participants of this study.ResultsA dose-response relationship between the FBG, HDL-c and CEA values and the PM2.5 exposure duration was observed. Multivariate analysis confirmed that one hour on duty outdoor per day for one year was associated with an increase in FBG of 0.005% (95% CI: 0.0004% to 0.009%), CEA of 0.012% (95% CI: 0.006% to 0.017%), and a decrease in HDL-C of 0.001% (95% CI: 0.00034% to 0.002%).ConclusionLong-term high air pollution exposure may lead to metabolism adaptation and it is likely involved in the development of cardiovascular disease and diabetes mellitus.