MRSA case studies.
MRSA case studies.
复制标题
MRSA 案例研究。
DOI：
10.1007/978-1-59745-468-1_2
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Shukla,SanjayK
中科院分区：
文献类型：
--
作者：
Reed,KurtD;Stemper,MaryE;Shukla,SanjayK
Staphylococcus aureusis a versatile pathogen associated with diverse clinical presentations. Only recently have the genetic factors underlying the virulence of this bacterial species become understood in a significant way. Methicillin-resistantS. aureus(MRSA) strains have been extremely important as nosocomial pathogens in health care facilities for more than three decades. Additionally, infections resulting from community-associated MRSA strains have emerged in the last decade and become a public health problem of global proportions. This changing epidemiology has spurred renewed interest in translating knowledge of the molecular determinants of virulence into rational prevention and control strategies. Four case histories are provided (three involving MRSA and one involving a methicillin-sensitive strain ofS. aureus) that highlight the diversity of clinical presentations and relative virulence ofS. aureusinfections in humans. The molecular characterization of clonality and virulence gene profile is compared among the four cases. Significant genetic diversity exists among MRSA and sensitive strains ofS. aureus. It is obvious that various combinations of virulence factors contribute to disease manifestations of infected patients.
