Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines.
Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines.
复制标题
甲型流感病毒血凝素在病毒进入以及抗病毒疗法和疫苗开发中的作用
DOI：
10.1007/s13238-010-0054-6
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发表时间：
2010-04
期刊：
影响因子：
21.1
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Jiang S;Li R;Du L;Liu S
季节性流感流行和由甲型流感病毒（IAV）引起的流感大流行已导致世界上数百万人死亡。为了预防和治疗IAV感染以及控制未来的流感大流行，迫切需要开发抗IAV疫苗和治疗剂。IAV血凝素（HA）在病毒的结合、融合和侵入过程中起关键作用，并含有主要的中和表位。因此，HA是开发抗IAV药物和疫苗的有吸引力的靶点。本文就HA在病毒融合过程中的构象变化及HA抗病毒药物和疫苗的研究进展作一综述。
Seasonal influenza epidemics and influenza pandemics caused by influenza A virus (IAV) has resulted in millions of deaths in the world. The development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza pandemics. Hemagglutinin (HA) of IAV plays a critical role in viral binding, fusion and entry, and contains the major neutralizing epitopes. Therefore, HA is an attractive target for developing anti-IAV drugs and vaccines. Here we have reviewed the recent progress in study of conformational changes of HA during viral fusion process and development of HA-based antiviral therapeutics and vaccines.