[4 + 3] Cycloaddition of ketenimines with furocarbenoids: Divergent and efficient synthesis of fused cycloheptatriene and tropone scaffolds
[4 + 3] Cycloaddition of ketenimines with furocarbenoids: Divergent and efficient synthesis of fused cycloheptatriene and tropone scaffolds
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DOI：
10.1016/j.cclet.2022.107823
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发表时间：
2022-09
影响因子：
9.1
通讯作者：
J. Wang;Zhaoyang Li;Shengxin Bai;Qinghua Zhou;Tengteng Wu;Zhongyan Hu;Xianxiu Xu
中科院分区：
文献类型：
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作者：
J. Wang;Zhaoyang Li;Shengxin Bai;Qinghua Zhou;Tengteng Wu;Zhongyan Hu;Xianxiu Xu
已经公开了呋喃酮亚胺与呋喃卡宾的前所未有的[4 + 3]环加成，用于环七呋喃和环七吡咯骨架的发散和有效合成。氯化锌作为促进剂，促进了这两种瞬时中间体从异氰化物和烯炔酮的形成，以及随后的七元环的构建。在这个三组分一锅多米诺反应中，三个环和五个键相继被构建。
An unprecedent [4 + 3] cycloaddition of furoketenimines with furocarbenoids has been disclosed for the divergent and efficient synthesis of cycloheptafuran and cycloheptapyrrole scaffolds. Zinc chloride acted as promoters for both the formation of these two transient intermediates from isocyanides and ene‑yne-ketones, and the subsequent construction of seven-membered ring. Three rings and five bonds were constructed successively in this three-component one-pot domino reaction.