Genetic control of longevity in C-elegans
Genetic control of longevity in C-elegans
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DOI：
10.1016/j.exger.2006.04.010
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发表时间：
2007-01-01
影响因子：
3.9
通讯作者：
Vanfleteren, Jacques R.
中科院分区：
文献类型：
--
作者：
Braeckman, Bart P.;Vanfleteren, Jacques R.
线虫秀丽隐杆线虫已被证明是研究长寿遗传学的一个非常有用的工具。已经发现超过70个基因影响这种蠕虫的寿命。与胰岛素/胰岛素样生长因子信号通路相关的是最好的研究之一，将集中在这次审查。这一途径的主要调节因子，叉头转录因子β 16，可以激活一个增强的生命维持计划，以响应环境和性腺的输入。β-16上调和下调许多基因的表达，导致代谢改变，增加压力和微生物抗性。这通常由生物化学和生理学数据证实。长寿突变体不是低代谢的，可能比野生型产生更多的活性氧。然而，它们的高抗氧化能力可能导致较低的氧化损伤。增强的分子周转率也可能在其长寿表型中发挥作用。(c)2006年爱思唯尔公司All rights reserved.
The nematode Caenorhabditis elegans has proven to be a very useful too] for studying the genetics of longevity. Over 70 genes have been found to influence lifespan in this worm. Those related to the Ins/IGF signaling pathway are among the best studied and will be focused on in this review. The master regulator of this pathway, the forkhead transcription factor DAF-16, can activate an enhanced life maintenance program in response to environmental and gonadal inputs. DAF-16 up- and downregulates expression of many genes leading to metabolic alterations and increased stress and microbial resistance. This is generally confirmed by biochemical and physiological data. Longevity mutants are not hypometabolic and probably produce more reactive oxygen species than wild type. However, their high antioxidant capacity may result in lower oxidative damage. Enhanced molecular turnover rates may also play a role in their longevity phenotype. (c) 2006 Elsevier Inc. All rights reserved.