Use of Pathogen-Specific Antibody Biomarkers to Estimate Waterborne Infections in Population-Based Settings.
Use of Pathogen-Specific Antibody Biomarkers to Estimate Waterborne Infections in Population-Based Settings.
复制标题
DOI：
10.1007/s40572-016-0096-x
复制
发表时间：
2016-09
影响因子：
7.9
通讯作者：
Heaney CD
中科院分区：
文献类型：
--
作者：
Exum NG;Pisanic N;Granger DA;Schwab KJ;Detrick B;Kosek M;Egorov AI;Griffin SM;Heaney CD
本文讨论了病原体特异性抗体生物标志物在改善对水传播感染人群负担的估计、评估可通过特定水处理预防的感染的比例以及了解不同人群中疾病的传播途径、自然历史和生态(包括无症状感染率)方面的应用。我们回顾了最近的文献，应用病原体特异性抗体反应数据来估计急性感染的发生率和流行率，以及它们在评估水媒传播途径的贡献方面的作用。在横断面和前瞻性调查中，讨论了血清抗体生物标志物与微创唾液抗体生物标记物的使用的优势和技术挑战。我们强调了最近的进展和挑战，并概述了基于抗体的和其他水传播感染的免疫生物标记物的研究、开发和应用的未来方向。
This review discusses the utility of pathogen-specific antibody biomarkers for improving estimates of the population burden of waterborne infections, assessing the fraction of infections that can be prevented by specific water treatments, and understanding transmission routes and the natural history and ecology of disease in different populations (including asymptomatic infection rates). We review recent literature on the application of pathogen-specific antibody response data to estimate incidence and prevalence of acute infections and their utility to assess the contributions of waterborne transmission pathways. Advantages and technical challenges associated with the use of serum versus minimally invasive salivary antibody biomarkers in cross-sectional and prospective surveys are discussed. We highlight recent advances and challenges and outline future directions for research, development, and application of antibody-based and other immunological biomarkers of waterborne infections.