Global molecular epidemiology of the O15:K52:H1 extraintestinal pathogenic Escherichia coli clonal group: evidence of distribution beyond Europe.
Global molecular epidemiology of the O15:K52:H1 extraintestinal pathogenic Escherichia coli clonal group: evidence of distribution beyond Europe.
复制标题
O15:K52:H1 肠外致病性大肠杆菌克隆群的全球分子流行病学：欧洲以外分布的证据。
DOI：
10.1128/jcm.40.6.1913-1923.2002
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发表时间：
2002
影响因子：
9.4
通讯作者：
Prats,Guillem
中科院分区：
文献类型：
--
作者：
Johnson,JamesR;Stell,AdamL;O'Bryan,TimothyT;Kuskowski,Michael;Nowicki,Bogdan;Johnson,Candice;Maslow,JoelN;Kaul,Anil;Kavle,Justine;Prats,Guillem
Escherichia coliO15:K52:H1 is a significant extraintestinal pathogen in Europe (G. Prats et al., J. Clin. Microbiol. 38:201-209, 2000). To search for evidence of this clonal group outside of Europe, 75 non-EuropeanE. coliisolates of serogroup O15 were compared with five members of the O15:K52:H1 clonal group from Barcelona, Spain, according to genomic background, virulence genotypes, and antimicrobial resistance profiles. Amplification phylotyping showed that 16 (21%) of the 75 non-European O15 isolates corresponded with the O15:K52:H1 clonal group. The 16 non-European O15:K52:H1 clonal group members represented diverse geographic locales. They were isolated almost exclusively from humans with extraintestinal infections and accounted for 50% of all O15 isolates from five human clinical collections studied. Most non-European clonal group members exhibited a consensus virulence factor profile that included the F16 or F7-2papAalleles (P fimbrial structural subunit),papGallele II (P fimbrial adhesin),iha(putative adhesin siderophore), andiutA(aerobactin receptor). This resembles the virulence profiles of (i) European representatives of the O15:K52:H1 clonal group and (ii) phylogenetically related “clonal group A,” a recently recognized significant contributor to trimethoprim-sulfamethoxazole resistance in the United States (A. R. Manges et al., N. Engl. J. Med. 345:1007-1013, 2001). Antimicrobial resistance profiles were variable, and resistance was inconsistently transferred by conjugation. These findings indicate that the O15:K52:H1 clonal group is broadly distributed beyond Europe, exhibits previously unrecognized phenotypic and genotypic diversity, and contributes significantly to extraintestinal infections in humans.
