Paramagnetic rim lesions and the central vein sign: Characterizing multiple sclerosis imaging markers.
Paramagnetic rim lesions and the central vein sign: Characterizing multiple sclerosis imaging markers.
复制标题
顺磁性边缘病变和中央静脉征：表征多发性硬化症成像标记物。
DOI：
10.1111/jon.13173
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Bagnato,Francesca
中科院分区：
文献类型：
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作者：
Clarke,MargaretaA;Cheek,Rachael;Kazimuddin,HabeebF;Hernandez,Bryan;Clarke,Reece;McKnight,ColinD;Derwenskus,Joy;Eaton,James;Irlmeier,Rebecca;Ye,Fei;O'Grady,KristinP;Rogers,Baxter;Smith,SethA;Bagnato,Francesca
背景和目的顺磁边缘和中央静脉征（CVS）是多发性硬化（MS）病变的影像学标志。使用7特斯拉磁共振成像，我们的目的是：（1）表征顺磁边缘病变（PRL）的外观;（2）评估PRL和CVS是否与较高水平的MS病理学相关;以及（3）比较在早期MS中有和没有PRL的受试者之间的特征。PRL和CVS。比较PRL和非PRL以及CVS阳性和CVS阴性病变之间的病变体积和大分子池大小比（PSR）指数（髓鞘完整性的代表）。在临床/人口统计学特征与PRL和那些没有患者之间的差异进行了tested.Results15例受试者有≥1 PRL共36个PRL，其中三分之二有一个完整的边缘。PRL预测病变尺寸较大，PSR信号降低。病变体积和颈椎病变的存在有显着差异的受试者与PRL和那些没有，虽然都没有保持显着调整后的多重比较。181个CVS病灶被确定，CVS阳性和CVS阴性病灶在体积（p= 0.27）和PSR值（p= 0.62）方面没有差异。结论PRL，但不是CVS阳性病灶，更大，髓鞘完整性更低。我们的研究结果表明，PRL与疾病改善治疗开始前较高水平的病变特异性病理学相关。
Background and PurposeParamagnetic rims and the central vein sign (CVS) are proposed imaging markers of multiple sclerosis (MS) lesions. Using 7 tesla magnetic resonance imaging, we aimed to: (1) characterize the appearance of paramagnetic rim lesions (PRLs); (2) assess whether PRLs and the CVS are associated with higher levels of MS pathology; and (3) compare the characteristics between subjects with and without PRLs in early MS.MethodsProspective study of 32 treatment‐naïve subjects around the time of diagnosis who were assessed for the presence of PRLs and the CVS. Comparisons of lesion volume and macromolecular pool size ratio (PSR) index, a proxy of myelin integrity, between PRLs and non‐PRLs, and CVS‐positive and CVS‐negative lesions were carried out. Differences in clinical/demographic characteristics between patients with PRLs and those without were tested.ResultsFifteen subjects had ≥1 PRL for a total of 36 PRLs, of which two‐thirds had a full rim. PRLs predicted a larger lesion size and decreased PSR signal. Lesion volume and presence of cervical spine lesions were significantly different between subjects with PRLs and those without, although neither remained significant after adjusting for multiple comparisons. One hundred and eighty‐one lesions with CVS were identified with no differences between CVS‐positive and CVS‐negative lesions in volume (p= .27) and PSR values (p= .62).ConclusionsPRLs, but not CVS‐positive lesions, are larger and have lower myelin integrity. Our findings indicate that PRLs are associated with higher levels of lesion‐specific pathology prior to the start of disease‐modifying therapy.