Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions
Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions
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cTAGE5/MEA6 介导的货物运输和生物学功能的分子机制
DOI：
10.1016/j.jgg.2022.04.001
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发表时间：
2022
影响因子：
5.9
通讯作者：
Xu Zhiheng
中科院分区：
文献类型：
--
作者：
Ma Tiantian;Zhang Feng;Wang Yaqing;Xu Zhiheng
外壳蛋白复合物II （COPII）包被的囊泡负责将货物从内质网（ER）运输到不同的目的地。cTAGE5/MEA6对不同器官的发育和功能至关重要。它通过与COPII组件的直接或间接互动来调节COPII承运人的组装和货物运输。cTAGE5/MEA6主要与另一种支架蛋白TANGO1协同，在多个器官的大小货物运输和分泌中发挥重要作用。从这个角度来看，我们想讨论cTAGE5/ mea6介导的货物运输和生物学功能的分子机制。
Coat protein complex II (COPII)-coated vesicles are responsible for transporting the cargoes from the endoplasmic reticulum (ER) to different destinations. cTAGE5/MEA6 is essential for the development and function of different organs. It regulates the assembly of COPII carrier and cargo trafficking through direct or indirect interaction with COPII components. cTAGE5/MEA6 mainly coordinates with another scaffold protein, TANGO1, to play essential roles in the trafficking and secretion of both large and small cargoes in multiple organs. In this viewpoint, we would like to discuss the molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions.