First Vesicular Self-Assembly of Crotocembraneic Acid, a Nano-Sized Fourteen Membered Macrocyclic Diterpenic Acid
First Vesicular Self-Assembly of Crotocembraneic Acid, a Nano-Sized Fourteen Membered Macrocyclic Diterpenic Acid
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DOI：
10.1002/slct.201700500
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发表时间：
2017-06-12
期刊：
影响因子：
2.1
通讯作者：
Kittakoop, Prasat
中科院分区：
文献类型：
--
作者：
Bag, Braja G.;Barai, Abir C.;Kittakoop, Prasat
近年来，分子在二元溶剂混合物水溶液中自发自组装产生囊泡自组装的研究一直是一个热门研究领域，因为它在控制释放药物输送系统、医疗植入物、组织工程等方面具有巨大的应用潜力。Crotocembraneic Acid 1是一种纳米级的14元大环二萜酸，可从Croton oblongifolius Roxb的叶子中提取。首次报道了纳米大环二萜类化合物1在二元混合溶剂中的自组装性质。二萜类化合物在二元溶剂混合物中自发自组装，产生纳米至微米直径的囊泡。囊泡自组装体能够捕获各种荧光团，包括抗癌药物阿霉素。
Study of the spontaneous self-assembly of molecules in aqueous binary solvent mixture yielding vesicular self-assemblies has been an area of intense research in recent years because of its tremendous potential application in controlled-release drug delivery systems, medical implants, tissue engineering, etc. Crotocembraneic acid1, a nano-sized 14-membered macrocyclic diterpenic acid, is extractable from the leaves of Croton oblongifolius Roxb. First self-assembly property of the nano-sized macrocyclic diterpenoid 1 in aqueous binary solvent mixtures is reported here. The diterpenoid spontaneously self-assembled in aqueous binary solvent mixtures yielding vesicles of nano- to micro-meter diameters. The vesicular self-assemblies were capable of entrapping various fluorophores including the anticancer drug doxorubicin.