DOPAMINERGIC MECHANISMS IN IDIOPATHIC AND DRUG-INDUCED PSYCHOSES
DOPAMINERGIC MECHANISMS IN IDIOPATHIC AND DRUG-INDUCED PSYCHOSES
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DOI：
10.1093/schbul/16.1.97
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发表时间：
1990-01-01
影响因子：
6.6
通讯作者：
LOEBEL, AD
中科院分区：
文献类型：
--
作者：
LIEBERMAN, JA;KINON, BJ;LOEBEL, AD
可卡因和苯丙胺等兴奋剂是精神分裂症患者最常滥用的药物之一。这可能部分是由于疾病和治疗副作用的方面，促使患者使用多巴胺激动剂药物。多巴胺能神经系统已被证明在兴奋剂效应和精神分裂症中起中介作用。由于精神分裂症的病理生理学假设与长期使用兴奋剂的神经生物学效应存在重叠，因此存在因滥用药物而导致原发疾病严重并发症的可能性。本文从精神分裂症的病理生理学理论出发，综述了与慢性兴奋剂给药相关的行为敏感化和神经毒性的神经生物学机制。讨论集中在使用兴奋剂对疾病过程的潜在影响以及精神分裂症的明显现象学和病程。
Stimulant drugs such as cocaine and amphetamine are among the most commonly abused substances by schizophrenic patients. This may be due in part to aspects of the illness and treatment side effects that impel patients to use dopamine agonist drugs. Dopaminergic neural systems have been shown to mediate both stimulant drug effects and schizophrenia. Because of the hypothesized overlap in the pathophysiology of schizophrenia and the neurobiological effects of chronic stimulant use, the potential for serious complication of the primary disease by substance abuse exists. This article reviews the neurobiological mechanisms of behavioral sensitization and neurotoxicity associated with chronic stimulant administration in the context of pathophysiological theories of schizophrenia. Discussion focuses on the potential impact of stimulant use on the disease process as well as the manifest phenomenology and course of schizophrenia.