Antral volume and propulsion-retropulsion in response to upper intestinal nutrients in a canine model.
Antral volume and propulsion-retropulsion in response to upper intestinal nutrients in a canine model.
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犬模型中上肠营养物质的窦体积和推进-反推力。
DOI：
10.1152/ajpgi.1993.264.6.g1077
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Malagelada,JR
中科院分区：
文献类型：
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作者：
Kumar,D;Ritman,EL;Malagelada,JR
我们使用动态空间重构器测量了三只雌性杂种狗的心房容积和单个蠕动周期的推进-后退力。我们的目的是量化肠道以10ml /min的速率在小肠上部灌注等量、等渗和等摩尔营养物质（麦麸，32.5 mg/ 100ml；酪蛋白水解物，32.5 mg/ 100ml；油酸15.5 mg/ 100ml）对总胃窦容积和“胃窦泵”的推进-推回功能的影响。等渗盐水作为对照溶液。等渗胃grafin （600ml）灌胃。采用6通道灌注测压装置记录心房相压活动。与其他营养物质或等渗盐水相比，脂肪灌注显著降低了胃窦容积（P < 0.05）。上小肠脂肪灌注显著降低了大鼠的推进-后退比（P < 0.05）。因此，我们的研究表明，输送到胃窦的液体膳食的比例，至少在一定程度上是由小肠上部的营养物质决定的，而且小肠中脂肪的存在改变了胃窦的推进-反推功能。
We measured antral volumes and propulsion-retropulsion for individual peristaltic cycles using the dynamic spatial reconstructor in three female mongrel dogs. Our aim was to quantify the effect of intestinal perfusion of equicaloric, isotonic, and isomolar nutrients (maltose, 32.5 mg/100 ml; casein hydrolysate, 32.5 mg/100 ml; and oleic acid 15.5 mg/100 ml) at a rate of 10 ml/min in the upper small intestine on total antral volume and the propulsion-retropulsion function of the "antral pump." Isotonic saline was used as a control solution. Isotonic gastrografin (600 ml) was instilled intragastrically as a meal. A 6-channel perfused manometric assembly was used to record antral phasic pressure activity. Antral volume was significantly lower (P < 0.05) in response to fat perfusion compared with other nutrients or isotonic saline. The propulsion-retropulsion ratio was also significantly reduced (P < 0.05) in response to fat perfusion in the upper small intestine. Our study, therefore, indicates that the fraction of a liquid meal delivered to the antrum is determined, at least in part, by the upper small intestinal nutrients and also that the presence of fat in the small intestine alters the propulsion-retropulsion function of the antrum.