MODELS OF HEPATIC DRUG CLEARANCE - DISCRIMINATION BETWEEN THE WELL STIRRED AND PARALLEL-TUBE MODELS
MODELS OF HEPATIC DRUG CLEARANCE - DISCRIMINATION BETWEEN THE WELL STIRRED AND PARALLEL-TUBE MODELS
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DOI：
10.1111/j.2042-7158.1983.tb02916.x
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发表时间：
1983-01-01
影响因子：
3.3
通讯作者：
ROWLAND, M
中科院分区：
文献类型：
--
作者：
AHMAD, AB;BENNETT, PN;ROWLAND, M
The predictive ability of 2 models of hepatic drug clearance are compared. The parallel-tube model predicts that the steady-state drug concentration following constant rate oral administration increases with increase in hepatic blood flow. The well-stirred model predicts that this parameter is not sensitive to changes in hepatic blood flow. Using the steady-state reservoir drug concentration as the discriminatory index, the predictions of the models were tested in a recirculating isolated perfused rat liver system with lignocaine and pethidone, both of which are highly extracted, as test drugs. The steady-state reservoir concentration of both drugs was constant when flow through the liver was increased from 10 ml min-1 to 15 ml min-1. The well-stirred model more accurately describes the elimination of highly cleared drugs with perturbations of flow than does the parallel-tube model.
