The initiation and propagation of hes7 oscillation are cooperatively regulated by fgf and notch signaling in the somite segmentation clock
The initiation and propagation of hes7 oscillation are cooperatively regulated by fgf and notch signaling in the somite segmentation clock
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DOI：
10.1016/j.devcel.2007.07.013
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发表时间：
2007-08-01
影响因子：
11.8
通讯作者：
Kageyama, Ryoichiro
中科院分区：
文献类型：
--
作者：
Niwa, Yasutaka;Masamizu, Yoshito;Kageyama, Ryoichiro
片段的周期性形成由分割时钟控制，其中振荡器Hes7调节Notch调制器Lunatic fringe的循环表达。在这里，我们发现Hes7也调节Fgf信号抑制剂Dusp4的循环表达，并将Notch和Fgf振荡相连接。引人注目的是，Notch信号的失活消除了这种传播，但允许Hes7振荡的启动。相比之下，Fgf信号的短暂失活消除了Hes7振荡的启动，而持续失活则消除了Hes7振荡的启动和传播。因此，我们认为Hes7振荡是由Fgf信号引发的，并在之前由Notch信号传播/维持。
Periodic formation of somites is controlled by the segmentation clock, where the oscillator Hes7 regulates cyclic expression of the Notch modulator Lunatic fringe. Here, we show that Hes7 also regulates cyclic expression of the Fgf signaling inhibitor Dusp4 and links Notch and Fgf oscillations in phase. Strikingly, inactivation of Notch signaling abolishes the propagation but allows the initiation of Hes7 oscillation. By contrast, transient inactivation of Fgf signaling abolishes the initiation, whereas sustained inactivation abolishes both the initiation and propagation of Hes7 oscillation. We thus propose that Hes7 oscillation is initiated by Fgf signaling and propagated/maintained anteriorly by Notch signaling.