POLYCLONAL INTEGRATION OF HTLV-I PROVIRAL DNA IN LYMPHOCYTES FROM HTLV-I SEROPOSITIVE INDIVIDUALS - AN INTERMEDIATE STATE BETWEEN THE HEALTHY CARRIER STATE AND SMOLDERING ATL
POLYCLONAL INTEGRATION OF HTLV-I PROVIRAL DNA IN LYMPHOCYTES FROM HTLV-I SEROPOSITIVE INDIVIDUALS - AN INTERMEDIATE STATE BETWEEN THE HEALTHY CARRIER STATE AND SMOLDERING ATL
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DOI：
10.1111/j.1365-2141.1988.tb06185.x
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发表时间：
1988-02-01
影响因子：
6.5
通讯作者：
TAKATSUKI, K
中科院分区：
文献类型：
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作者：
YAMAGUCHI, K;KIYOKAWA, T;TAKATSUKI, K
我们研究了15例血清中HTLV-I抗体阳性和外周血淋巴细胞中HTLV-I前病毒DNA随机整合的个体(年龄14-74岁)。除了一名患者外，所有患者都患有各种非特异性主诉，这与成人T细胞白血病(ATL)的主诉不一致。他们都出生在九州和冲绳，这两个地区是HTLV-I感染的流行区；他们的家庭成员中也有25%的人HTLV-I血清阳性。这些患者唯一的血液学异常是外周血中存在极少的非典型淋巴样细胞。CD_4/CD_8比值正常，但Tac阳性细胞比例略高于正常。这些具有HTLV-I前病毒DNA多克隆整合的个体似乎代表了阴燃的ATL(单克隆性整合)和健康的HTLV-I携带者(有抗体但没有检测到HTLV-I前病毒DNA)之间的中间状态。HTLV-I感染处于中间状态的患者可能有进展为ATL的风险。根据这些新发现，回顾了人类感染HTLV-I导致ATL发展的自然历史。
We have studied 15 individuals (aged 14-74 years) with antibodies to HTLV-I in their serum and random integration of HTLV-I proviral DNA in their peripheral blood lymphocytes. All but one of these patients suffered from a variety of non-specific complaints which did not correspond to those of adult T-cell leukaemia (ATL). All of them were born in Kyushu and Okinawa which are endemic areas for HTLV-I infection; 25% of their family members were also seropositive for HTLV-I. The only haematological abnormality in these patients was the presence of few atypical lymphoid cells in the peripheral blood. The CD4/CD8 ratios were normal but the proportion of Tac positive cells was slightly higher than normal. These individuals with polyclonal integration of HTLV-I proviral DNA seem to represent an intemediate state between smouldering ATL (monoclonal integration) and healthy HTLV-I carriers (with antibodies but no detectable HTLV-I proviral DNA). Patients with this intermediate state of HTLV-I infection may be at risk to progress to ATL. The natural history of HTLV-I infection in humans leading to the development of ATL is reviewed in the light of these new findings.