Ecological Therapeutic Opportunities for Oral Diseases.
Ecological Therapeutic Opportunities for Oral Diseases.
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口腔疾病的生态治疗机会。
DOI：
10.1128/microbiolspec.bad-0006-2016
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发表时间：
2017-08
影响因子：
3.7
通讯作者：
Diaz PI
中科院分区：
文献类型：
--
作者：
Hoare A;Marsh PD;Diaz PI
人类的三种主要口腔疾病，即龋齿、牙周病和口腔念珠菌病，与由口腔环境的变化和/或粘膜免疫监视的有效性降低引发的微生物组变化相关。在这篇综述中，我们讨论了微生物疗法在控制这些疾病中的作用。大多数关于使用微生物管理口腔疾病的研究都是使用益生菌菌株进行的，具有一些积极但非常离散的临床结果。其他策略，如整个口腔微生物组移植或通过富集促进健康的本土口腔菌株来改变社区功能，可能会提供更多的希望，但这一领域的研究仍处于起步阶段。然而，任何基于微生物的口腔疾病治疗方法都可能只是整体预防策略中的一个组成部分，该策略还应旨在改变与口腔生态失调相关的微生物组变化的启动和持续的环境影响。
The three main oral diseases of humans, that is caries, periodontal diseases and oral candidiasis, are associated with microbiome shifts initiated by changes in the oral environment and/or decreased effectiveness of mucosal immune surveillance. In this review we discuss the role that microbial-based therapies may have in the control of these conditions. Most investigations on the use of microorganisms for management of oral disease have been conducted with probiotic strains with some positive but very discrete clinical outcomes. Other strategies such as whole oral microbiome transplantation or modification of community function by enrichment with health-promoting indigenous oral strains may offer more promise but research in this field is still in its infancy. Any microbial-based therapeutics for oral conditions, however, are likely to be only one component within a holistic preventive strategy that should also aim at modification of the environmental influences responsible for the initiation and perpetuation of microbiome shifts associated with oral dysbiosis.