Central memory CD4+ T cell responses in chronic HIV infection are not restored by antiretroviral therapy
Central memory CD4+ T cell responses in chronic HIV infection are not restored by antiretroviral therapy
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DOI：
10.4049/jimmunol.173.3.2184
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发表时间：
2004-08-01
影响因子：
4.4
通讯作者：
Cao, HY
中科院分区：
文献类型：
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作者：
Elrefaei, M;McElroy, MD;Cao, HY
强烈的 CD4(+) T 细胞反应与更好地控制 HIV 感染相关。然而，HIV 对 Ag 特异性记忆 CD4(+) T 细胞的维持的影响尚不完全清楚。我们对接受高效抗逆转录病毒治疗的 HIV 感染者 (n = 21)、HIV 感染者长期无进展者 (n = 10) 和 HIV 血清阴性志愿者 (n = 10) 中由腮腺炎和甲型或乙型流感病毒产生的记忆 CD4(+) T 细胞的功能和表型进行了表征。我们观察到，与血清阴性对照相比，抗逆转录病毒治疗的 HIV 感染者中 Ag 特异性中央记忆 CD4(+) T 细胞群 (CD28(+)/CCR7(+)/CD45RA(-)) 的增殖显着下降。在高活性抗逆转录病毒治疗期间恢复CD4（+）T细胞计数和降低HIV病毒载量并不会导致增殖增加，而最低点CD4（+）T细胞计数预示着Ag特异性增殖的存在。我们的研究结果表明，HIV 感染会导致病毒诱导的或疫苗产生的中央记忆 CD4(+) T 细胞的维持受损，而 HAART 无法恢复这些细胞。
A strong CD4(+) T cell response has been correlated with better control of HIV infection. However, the effect of HIV on the maintenance of Ag-specific memory CD4(+) T cells is not fully understood. We characterized the function and phenotype of memory CD4(+) T cells generated by mumps and influenza A or B viruses in HIV-infected individuals receiving highly active antiretroviral therapy (n = 21), HIV-infected long-term nonprogressors (n = 10), and HIV-seronegative volunteers (n = 10). We observed significantly decreased proliferation of the Ag-specific central memory CD4(+) T cell population (CD28(+)/CCR7(+)/CD45RA(-)) in the antiretroviral treated HIV-infected individuals compared with the seronegative controls. Restored CD4(+) T cell count and decreased HIV viral load while on highly active antiretroviral therapy did not result in increased proliferation, whereas nadir CD4(+) T cell count predicted the presence of Ag-specific proliferation. Our results indicate that HIV infection leads to impaired maintenance of virus-induced or vaccine-generated central memory CD4(+) T cells that is not restored by HAART.