Vascular anastomosis using controlled phase transitions in poloxamer gels
Vascular anastomosis using controlled phase transitions in poloxamer gels
复制标题
DOI：
10.1038/nm.2424
复制
发表时间：
2011-09-01
期刊：
影响因子：
82.9
通讯作者：
Gurtner, Geoffrey C.
中科院分区：
文献类型：
--
作者：
Chang, Edward I.;Galvez, Michael G.;Gurtner, Geoffrey C.
血管吻合是血管、心血管和移植手术的基石。大多数吻合术都是用缝线进行的，这在技术上是有挑战性的，可能会导致内膜增生和异物反应失败。已经提出了许多替代缝合的方法，但没有一种方法被证明是优越的，特别是在小血管或动脉粥样硬化的血管中。我们开发了一种新的无缝合和无创伤性血管吻合方法，该方法使用美国食品和药物管理局(FDA)批准的热可逆三嵌段聚合物暂时保持开放的管腔，以与商业胶水精确接近。我们进行端到端吻合的速度是手工缝合对照的五倍，而且血管太小(
Vascular anastomosis is the cornerstone of vascular, cardiovascular and transplant surgery. Most anastomoses are performed with sutures, which are technically challenging and can lead to failure from intimal hyperplasia and foreign body reaction. Numerous alternatives to sutures have been proposed, but none has proven superior, particularly in small or atherosclerotic vessels. We have developed a new method of sutureless and atraumatic vascular anastomosis that uses US Food and Drug Administration (FDA)-approved thermoreversible tri-block polymers to temporarily maintain an open lumen for precise approximation with commercially available glues. We performed end-to-end anastomoses five times more rapidly than we performed hand-sewn controls, and vessels that were too small (