Imaging of Sodium MRI for Therapy Evaluation of Brain Metastase with Cyberknife at 7T: A Case Report.
Imaging of Sodium MRI for Therapy Evaluation of Brain Metastase with Cyberknife at 7T: A Case Report.
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DOI：
10.7759/cureus.2502
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发表时间：
2018-04-18
期刊：
影响因子：
--
通讯作者：
Pan L
中科院分区：
文献类型：
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作者：
Huang L;Zhang Z;Qu B;Cui Z;Wang Y;Li J;Wang J;Zuo Z;Zhuo Y;Yu X;Lin Z;Pan L
在这里，我们描述的情况下，一个老年患者谁提出了最近的历史，右眼视力受损约三个月，由于脑部病变。他被诊断出患有肝癌，三个月前接受了手术。病理结果为肝细胞癌。磁共振成像（MRI）显示诊断为脑转移。由于患者的身体状况不适合开颅手术，因此选择了CyberKnife （Accuray Incorporated, Sunnyvale， USA）放射治疗脑损伤。我们采用7T磁共振成像系统的钠核磁共振成像和质子扩散成像来评估射波刀早期治疗后的疗效。到目前为止，我们发现组织钠浓度（TSC）随时间变化，而质子MRI在一个月内没有明显变化。治疗后脑肿瘤内钠浓度的时间过程较治疗前和立体定向放射治疗后48小时显著升高，这与放疗诱导细胞坏死的时间有关。本病例证明了钠磁共振成像作为监测早期放疗以评估肿瘤细胞的生物标志物的可能性。
Herein we describe the case of an elderly patient who presented with a recent history of impaired vision of the right eye around three months due to brain lesions. He was diagnosed with liver cancer and underwent surgery three months prior. The pathological result is hepatocellular carcinoma. Magnetic resonance imaging (MRI) revealed the diagnosis of brain to be metastatic. The patient selected CyberKnife (Accuray Incorporated, Sunnyvale, USA) radiosurgery for the brain lesion since his physical conditions are not suitable for craniotomy. We adapt the imaging of sodium MRI and proton diffusion mapping at 7T MR system to evaluate the efficacy following CyberKnife early stage treatment. To date, we find the tissue sodium concentration (TSC) changes with the time whereas the proton MRI has no significant change within one month. The time course of sodium concentration in the tumor showed a dramatic increase in the treated brain tumor compared to the pretreatment sodium concentration and 48 hours after stereotactic radiosurgery (SRS), which is correlated to the period of the radiotherapy-induced cellular necrosis. This case demonstrates the possibility of sodium MRI as a biomarker for monitoring early radiotherapy for assessing tumor cellularity.