Lexical decision in Parkinson disease: lack of evidence for generalized bradyphrenia.
Lexical decision in Parkinson disease: lack of evidence for generalized bradyphrenia.
复制标题
帕金森病的词汇决策：缺乏全身性迟缓症的证据。
DOI：
10.1080/01688639408402656
复制
发表时间：
1994
影响因子：
2.2
通讯作者：
J. Gorell
中科院分区：
文献类型：
--
作者：
K. Spicer;G. G. Brown;J. Gorell
22名非痴呆患者与特发性帕金森病（PD）和22名对照完成了词汇决策任务的预期之间的关系启动和目标被操纵。测量反应时间和运动时间。与中性条件相比，PD受试者在利用启动线索减少反应时间方面与对照组一样有效。这种促进作用甚至发生在最短的刺激开始时（300 ms），并且在需要转移注意力的条件下观察到，这表明PD患者没有经历一般的认知减慢，也没有困难有效地将注意力转移到指定的语义类别。在几项比较中，PD组的易化程度显著更高，表明过度启动。最后，预期启动促进运动时间在PD组。虽然研究结果不支持非痴呆性帕金森病患者存在广泛性智力迟钝，但超启动效应和词汇得分与选择反应时间的相关性分析确实提高了PD患者存在细微语义处理缺陷或战略决策障碍的可能性。
Twenty-two nondemented patients with idiopathic Parkinson disease (PD) and 22 controls completed a lexical decision task for which the expected relationship between primes and targets was manipulated. Both reaction times and movement times were measured. PD subjects were as effective as controls in utilizing the priming cues to reduce their reaction times compared with a neutral condition. This facilitation occurred even at the shortest stimulus onset asynchrony employed (300 ms), and was observed in a condition requiring a shift of attention, suggesting that PD patients experience no general cognitive slowing and no difficulty efficiently shifting attention to a specified semantic category. The degree of facilitation was significantly greater in the PD group in several comparisons, indicating hyperpriming. Finally, expectancy primes facilitated movement times in the PD group only. Although the results do not support the existence of generalized bradyphrenia in nondemented Parkinson disease, the hyperpriming effect and correlational analyses involving vocabulary scores and choice reaction time do raise the possibility of a subtle semantic processing deficit or an impairment of strategic decision-making in PD.