A BRIEF REVIEW ON THE MODE OF ACTION OF ANTINEMATODAL DRUGS.
A BRIEF REVIEW ON THE MODE OF ACTION OF ANTINEMATODAL DRUGS.
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DOI：
10.1515/acve-2017-0013
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
Robertson AP
中科院分区：
文献类型：
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作者：
Abongwa M;Martin RJ;Robertson AP
驱虫药是兽医学中使用最广泛的药物之一。本文综述了这些化合物对线虫寄生虫的作用机制。包括较老的化合物类别；苯并咪唑、胆碱能激动剂和大环内酯。我们也考虑较新的驱虫剂，包括emodepside， derquantel和tribendimidine。在大多数寄生虫缺乏疫苗的情况下，控制线虫寄生虫将继续依赖驱虫药。因此，需要警惕地发现寄生虫种群中的耐药性。由于耐药性的发展几乎是不可避免的，因此有一个持续和迫切的需要，以充分了解这些化合物的作用模式。为持续有效地控制线虫寄生虫，有必要寻找新的药物靶点和药物。
Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required. Since resistance development appears almost inevitable, there is a continued and pressing need to fully understand the mode of action of these compounds. It is also necessary to identify new drug targets and drugs for the continued effective control of nematode parasites.