mir-17-92: a polycistronic oncomir with pleiotropic functions.
mir-17-92: a polycistronic oncomir with pleiotropic functions.
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DOI：
10.1111/imr.12054
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发表时间：
2013-05
影响因子：
8.7
通讯作者：
He L
中科院分区：
文献类型：
--
作者：
Olive V;Li Q;He L
肿瘤转化是由于遗传损伤的积累，最终将正常细胞转化为具有不受控制的增殖和存活、无限复制潜力和侵袭性生长的肿瘤细胞。新的证据强调了非编码RNA，特别是microRNAs(MiRNAs)在肿瘤发生和发展中的功能重要性。Mir-17-92miRNA是最具特征的miRNA癌基因之一，其基因组扩增或异常升高常见于各种肿瘤类型。与编码蛋白质的癌基因不同，一个转录本产生一种蛋白质，而mir-17-92编码一个多顺反子miRNA转录本，产生六个单独的miRNA成分。这种独特的基因结构，由许多重要的miRNA癌基因和肿瘤抑制基因共享，以细胞类型和上下文相关的方式奠定了mir-17-92独特的功能。最近对mir-17-92的功能分析表明，单独的mir-17-92组分具有不同的生物学功能，在发育和疾病过程中共同调节多种相关的细胞过程。Mir-17-92作为一种多顺反子miRNA癌基因，其结构的复杂性及其各组分之间复杂的相互作用模式，构成了其在正常和肿瘤发展过程中独特功能复杂性的分子基础。
Neoplastic transformation is caused by accumulation of genetic lesions that ultimately convert normal cells into tumor cells with uncontrolled proliferation and survival, unlimited replicative potential, and invasive growth. Emerging evidence has highlighted the functional importance of non-coding RNAs, particularly microRNAs (miRNAs), in the initiation and progression of tumor development. The mir-17-92 miRNA is among the best characterized miRNA oncogenes, whose genomic amplification or aberrant elevation are frequently observed in a variety of tumor types. Unlike protein-coding oncogenes, where one transcript produces one protein, mir-17-92 encodes a polycistronic miRNA transcript that yields six individual miRNA components. This unique gene structure, shared by many important miRNA oncogenes and tumor suppressors, underlies the unique functionality of mir-17-92 in a cell type and context dependent manner. Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease. The structural complexity of mir-17-92 as a polycistronic miRNA oncogene, along with the complex mode of interactions among its components, constitute the molecular basis for its unique functional complexity during normal and tumor development
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影响因子：
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影响因子：
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