MR venography of the human brain using susceptibility weighted imaging at very high field strength
MR venography of the human brain using susceptibility weighted imaging at very high field strength
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DOI：
10.1007/s10334-007-0101-3
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发表时间：
2008-03-01
影响因子：
2.3
通讯作者：
Barth, Markus
中科院分区：
文献类型：
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作者：
Koopmans, Peter J.;Manniesing, Rashindra;Barth, Markus
目的探讨强磁场对磁化率加权成像(SWI)磁共振静脉成像的影响，并估算获得最大血液与脑组织对比度的最佳回声时间。材料与方法测量活体灰质、白质和静脉血在7T时的组织对比度和T*(2)弛豫时间。结果活体灰质、白质和静脉血的T*(2)弛豫时间分别为32.9±2.3、27.7+/-4.3和7.4±1.4ms。最佳TE为15ms，这得到了理论上的支持。利用这种优化的TE，我们在短时间内获得了大体积覆盖的3D高分辨率数据集，这些数据集显示了非常详细的人脑的显微解剖结构，如皮质内静脉和皮质下层结构。结论应用优化的血管滤光片(血管滤光片和血管增强扩散)，可以在7T获得全脑MR静脉图像，与3T相比，测量时间显著缩短。
Objective We investigate the implications of high magnetic field strength on MR venography based on susceptibility-weighted imaging (SWI) and estimate the optimum echo time to obtain maximum contrast between blood and brain tissue.Materials and methods We measured tissue contrast and T*(2) relaxation times at 7 T of gray matter, white matter, and venous blood in vivo.Results T*(2) relaxation times of gray matter, white matter, and venous blood in vivo yielded 32.9 +/- 2.3, 27.7 +/- 4.3, and 7.4 +/- 1.4 ms, respectively. Optimum TE was found to be 15 ms which is supported by theoretical considerations. Using this optimum TE, we acquired 3D high resolution datasets with a large volume coverage in a short measurement time that show very detailed microanatomical structures of the human brain such as intracortical veins and laminar cortical substructures.Conclusions By applying optimised vessel filters (vesselness filter and vessel enhancing diffusion) whole brain MR venograms can be obtained at 7 T with a significantly reduced measurement time compared to 3 T.