Research advances in pericyte function and their roles in diseases

Research advances in pericyte function and their roles in diseases
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周细胞功能及其在疾病中作用的研究进展

DOI:
10.1016/j.cjtee.2020.02.006
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发表时间:
2020
影响因子:
2.1
通讯作者:
Liangming Liu
Liangming Liu
中科院分区:
医学4区
文献类型:
--
作者:
Zisen Zhang;Henan Zhou;S. He;Mingying Xue;Tao Li;Liangming Liu

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周细胞是一种多能性细胞,可调节微循环的灌流和通透性。周细胞与平滑肌细胞相似,表达多种收缩蛋白,具有收缩性。周细胞的功能障碍与许多微血管疾病有关,包括缺氧、高血压、糖尿病视网膜病变、纤维化、炎症、阿尔茨海默病、多发性硬化和肿瘤形成。长期以来,它们的存在和功能被忽视。本文就周细胞的分布、结构、生物标志物、相关信号通路及其在血管疾病中的作用作一综述。
Pericyte, a kind of pluripotent cell, may regulate the irrigation flow and permeability of microcirculation. Pericytes are similar to the smooth muscle cells, which express several kinds of contractile proteins and have contractility. The dysfunction of pericytes is related to many microvascular diseases, including hypoxia, hypertension, diabetic retinopathy, fibrosis, inflammation, Alzheimer's disease, multiple sclerosis, and tumor formation. For a long time, their existence and function have been neglected. The distribution, structure, biomarker, related signaling pathways as well as the roles of pericytes on vascular diseases will be introduced in this review.
DOI: 10.1016/j.stem.2012.07.007
发表时间: 2012-10-05
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