Assessing an Intervention to Improve Clinical Trial Perceptions Among Predominately African-American Communities in South Carolina
Assessing an Intervention to Improve Clinical Trial Perceptions Among Predominately African-American Communities in South Carolina
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DOI：
10.1353/cpr.2012.0038
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发表时间：
2012-09-01
影响因子：
1.1
通讯作者：
Garrett-Mayer, Elizabeth
中科院分区：
文献类型：
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作者：
Ford, Marvella;Wahlquist, Amy;Garrett-Mayer, Elizabeth
背景：尽管非洲裔美国人(AA)的癌症死亡率明显高于欧美裔美国人(EA)，但他们在癌症临床试验中的代表性并不好。目的：本研究的目的是评估一项改善非洲裔美国人对癌症临床试验认知的计划。方法：该计划以方便抽样的方式进行，195名参与者(75.4%的AA)居住在癌症死亡率种族差异较高的县，他们是由社区合作伙伴招募的。这项30分钟的计划是3.5小时癌症教育计划的一部分，由美国国立卫生研究院(NIH)/美国国家癌症研究所(NCI)联合开发。它被修改为包括AA、AA特定癌症死亡率数据的附加图片，以及关于塔斯基吉梅毒研究和由此产生的改进的参与者保护措施的信息。测量：使用对随机试验问卷(ARTQ)的七个项目的态度来评估试验知觉从试验前到试验后的变化。结果：略多于一半的受访者至少有大学文凭(54.4%)，45.1%的人已婚/已婚生活，53.3%的人为女性，45.6%的人家庭年收入低于4万美元。对于每个ARTQ项目，大多数参与者在前测时对试验的看法不太好，在后测时变得更积极(p<；.001)。结论：提供癌症临床试验信息会导致对癌症临床试验的更积极的看法。在未来的研究中，该计划可以用来帮助潜在的试验参与者做出关于参与的知情决定；然后可以评估试验的注册率。
Background: African Americans (AA) are not well-represented in cancer clinical trials despite having significantly higher cancer mortality rates than their European-American (EA) counterparts.Objectives: The purpose of this study was to evaluate a program to improve perceptions of cancer clinical trials among AA.Methods: The program was conducted in a convenience sample of 195 participants (75.4% AA) who lived in counties with high racial disparities in cancer mortality rates and who were recruited by community partners. The 30-minute program, part of a larger 3.5-hour cancer education program, was developed by the National Institutes of Health (NIH)/National Cancer Institute (NCI). It was modified to include additional pictures of AA, AA-specific cancer mortality data, and information about the Tuskegee Syphilis Study and the resulting improved participant protection measures.Measures: The seven-item Attitudes to Randomized Trial Questionnaire (ARTQ) was used to evaluate changes in trial perceptions from pre- to posttest. Additional survey items assessed general demographic characteristics.Results: Slightly more than half of the participants had at least a college diploma (54.4%), 45.1% were married/living as married, 53.3% were female, and 45.6% had an annual household income of less than $40,000. For each ARTQ item, most participants who had less favorable perceptions of trials at pretest changed to more positive perceptions at posttest (p < .001).Conclusions: Providing cancer clinical trial information led to more positive perceptions of cancer clinical trials. In future studies, the program could be used to help potential trial participants make informed decisions about participation; trial enrollment rates could then be evaluated.