Factors associated with sputum culture conversion in multidrug-resistant pulmonary tuberculosis
Factors associated with sputum culture conversion in multidrug-resistant pulmonary tuberculosis
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DOI：
10.5588/ijtld.16.0096
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发表时间：
2016-12-01
影响因子：
4
通讯作者：
Swaminathan, S.
中科院分区：
文献类型：
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作者：
Velayutham, B.;Nair, D.;Swaminathan, S.
简介：耐多药肺结核 (MDR-TB) 的痰培养转换对于制定治疗相关决策和预防疾病传播非常重要。目的：确定与痰培养转换相关的因素，确定培养转换的时间以及培养转换对耐多药/利福平 (RMP) 结核病成功治疗结果的影响。方法：对治疗卡和患者登记册中的数据进行回顾性分析。 2009 年 1 月至 2011 年 12 月，耐多药/耐多药耐药患者在德里、西孟加拉邦和喀拉拉邦根据印度修订后的国家结核病控制计划开始接受治疗。计算比例并进行逻辑回归分析。结果：在 836 名患者中，787 名患者进行了分析，其中 651 名患者 (83%) 经历了培养物转化：在第 3、4 个月分别有 57%、73% 和 79% 的培养物转化和6次治疗。培养物转化的中位时间为 91.3 天。体重指数（BMI）患者
INTRODUCTION:Sputum culture conversion in pulmonary multidrug-resistant tuberculosis (MDR-TB) is important to make treatment-related decisions and prevent transmission of disease.OBJECTIVE: To identify factors associated with sputum culture conversion, and to determine time to culture conversion and the impact of culture conversion on successful treatment outcomes in MDR-/rifampicin (RMP) resistant TB.METHOD: Retrospective analysis of data from treatment cards and registers of MDR-/RMP-resistant patients initiated on treatment under India's Revised National TB Control Programme in Delhi, West Bengal and Kerala from January 2009 to December 2011. Proportions were calculated and logistic regression analysis was performed.RESULTS: Of 836 patients, 787 were analysed, 651 (83%) of whom experienced culture conversion: respectively 57%, 73% and 79% culture converted by month 3, 4 and 6 of treatment. The median time to culture conversion was 91.3 days. Patients with body mass index (BMI)