Sweeping lymph node micrometastases off their feet: an engineered model to evaluate natural killer cell mediated therapeutic intervention of circulating tumor cells that disseminate to the lymph nodes
Sweeping lymph node micrometastases off their feet: an engineered model to evaluate natural killer cell mediated therapeutic intervention of circulating tumor cells that disseminate to the lymph nodes
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DOI：
10.1039/c3lc50584g
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发表时间：
2014-01-01
期刊：
影响因子：
6.1
通讯作者：
King, Michael R.
中科院分区：
文献类型：
--
作者：
Chandrasekaran, Siddarth;McGuire, Matthew J.;King, Michael R.
大约90%的癌症相关死亡是由于转移。来自原发性肿瘤的细胞可以通过血管或淋巴循环转移。循环中的癌细胞被称为循环肿瘤细胞（CTC），并且已经显示骨髓是来自几种上皮肿瘤的血液传播CTC归巢的小生境。在骨髓中发现的癌细胞被称为播散性肿瘤细胞（DTC）。同样，淋巴循环中的CTC更经常接种在排出肿瘤的前哨淋巴结（SLN）中。微转移（
Approximately 90% of cancer related deaths are due to metastasis. Cells from the primary tumor can metastasize through either the vascular or lymphatic circulation. Cancer cells in circulation are called circulating tumor cells (CTCs) and it has been shown that bone marrow is a niche for homing of blood borne CTCs from several epithelial tumors. Cancer cells found in bone marrow are termed disseminated tumor cells (DTCs). Likewise, CTCs in the lymphatic circulation are more often seeded in the sentinel lymph nodes (SLN) that drain the tumor. Micrometastases (