Multi-Toxic Endpoints of the Foodborne Mycotoxins in Nematode Caenorhabditis elegans.
Multi-Toxic Endpoints of the Foodborne Mycotoxins in Nematode Caenorhabditis elegans.
复制标题
线虫秀丽隐杆线虫中食源性霉菌毒素的多毒性终点。
DOI：
10.3390/toxins7124876
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发表时间：
2015-12-02
期刊：
影响因子：
4.2
通讯作者：
Wang JS
中科院分区：
文献类型：
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作者：
Yang Z;Xue KS;Sun X;Tang L;Wang JS
黄曲霉毒素B1（AFB 1）、脱氧雪腐镰刀菌烯醇（DON）、伏马菌素B1（FB 1）、T-2毒素（T-2）和玉米赤霉烯酮（ZEA）是引起公众健康关注的主要食源性真菌毒素。在本研究中，在秀丽隐杆线虫模型中评估了这些天然存在的真菌毒素的多个毒性终点，以评估其致死率、对生长和繁殖的毒性作用以及对寿命的影响。我们发现，致死终点对T-2毒性更敏感，EC 50为1.38 mg/L，生长终点对AFB 1毒性效应相对敏感，繁殖终点对AFB 1、FB 1和ZEA毒性效应更敏感。此外，寿命终点对所有五种测试真菌毒素的毒性作用敏感。本研究所得数据可作为评估霉菌毒素毒性效应知识的重要贡献，特别是用于评估发育和生殖毒性效应，使用C。elegans模型
Aflatoxins B1 (AFB1), deoxynivalenol (DON), fumonisin B1 (FB1), T-2 toxin (T-2), and zearalenone (ZEA) are the major foodborne mycotoxins of public health concerns. In the present study, the multiple toxic endpoints of these naturally-occurring mycotoxins were evaluated in Caenorhabditis elegans model for their lethality, toxic effects on growth and reproduction, as well as influence on lifespan. We found that the lethality endpoint was more sensitive for T-2 toxicity with the EC50 at 1.38 mg/L, the growth endpoint was relatively sensitive for AFB1 toxic effects, and the reproduction endpoint was more sensitive for toxicities of AFB1, FB1, and ZEA. Moreover, the lifespan endpoint was sensitive to toxic effects of all five tested mycotoxins. Data obtained from this study may serve as an important contribution to knowledge on assessment of mycotoxin toxic effects, especially for assessing developmental and reproductive toxic effects, using the C. elegans model.