Genetic and environmental influences on drug use and abuse/dependence in male and female twins
Genetic and environmental influences on drug use and abuse/dependence in male and female twins
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DOI：
10.1016/s0376-8716(98)00101-x
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发表时间：
1998-11-01
影响因子：
4.2
通讯作者：
Pickens, RW
中科院分区：
文献类型：
--
作者：
van den Bree, MBM;Johnson, EO;Pickens, RW
双胞胎是通过酒精和药物治疗计划招募的。通过结构方程建模，获得了镇静剂、阿片类药物、可卡因、兴奋剂和大麻以及任何非法药物的使用和DSM-III滥用/依赖的遗传和环境估计。分别对雄性和雌性动物进行分析。模型包括基于吸毒或滥用/依赖的人口流行率和曾经接受过治疗的阈值。遗传影响被发现的大多数措施。一般而言，男性比女性更强，滥用/依赖的临床诊断比使用更强。常见的环境影响在使用方面比滥用方面发挥更大的作用：依赖。(C)1998爱思唯尔科学爱尔兰有限公司保留所有权利。
Twins were recruited through alcohol and drug treatment programs. With structural equation modeling, genetic and environmental estimates were obtained for use and DSM-III abuse/dependence of sedatives, opioids, cocaine, stimulants, and cannabis as well as any illicit drug. Analyses were conducted separately for males and females. Models included thresholds based on population prevalence of use or abuse/dependence and ever having been in treatment. Genetic influences were found for most measures. They were generally stronger for males than females and for clinical diagnoses of abuse/dependence compared to use. Common environmental influences played a greater role in use than abuse:dependence. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.