Immunohistochemical localization of histamine receptor subtypes in human inferior turbinates
Immunohistochemical localization of histamine receptor subtypes in human inferior turbinates
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DOI：
10.1177/000348940411300707
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发表时间：
2004-07-01
影响因子：
1.4
通讯作者：
Kondo, K
中科院分区：
文献类型：
--
作者：
Nakaya, M;Takeuchi, N;Kondo, K
组胺是变应性鼻炎的重要化学介质，在引起变应性鼻炎的鼻症状中起重要作用。然而，组胺受体亚型（H1R、H2R、H3R和H4R）在人鼻黏膜中的免疫组织化学定位尚不清楚。H3R和H4R在人鼻黏膜中的研究也未见报道。本研究的目的是通过免疫组织化学方法检测组胺受体亚型在人下鼻甲中的分布。H1R主要局限于上皮、血管和神经。H2R主要定位于上皮和腺体。H3R和H4R在神经上分布明显。此外，H1R、H3R和H4R明显定位于同一神经。说明在同一神经中，H1R、H3R和H4R是相互连接、相互调节的。所有组胺受体亚型都可能在变应性鼻炎患者中发挥一定作用。
Histamine is an important chemical mediator in allergic rhinitis and plays an important role in eliciting the nasal symptoms of the disorder. However, the immunohistochemical localization of histamine receptor subtypes (H1R, H2R, H3R, and H4R) in human nasal mucosa is unknown. There are also no prior studies of H3R and H4R in human nasal mucosa. The objective of this study was to examine the distribution of histamine receptor subtypes in the human inferior turbinates by an immunohistochemical method. H1R was localized primarily in the epithelium, vessels, and nerves. H2R was localized primarily in the epithelium and the glands. H3R and H4R were clearly distributed on the nerves. In addition, H1R, H3R, and H4R were clearly localized on the same nerves. This result indicates that H1R, H3R, and H4R adjoin and regulate each other in the same nerves. All histamine receptor subtypes may play some role in patients with allergic rhinitis.