Clinical significance of measuring the blood concentration of itraconazole oral solution in the field of hematology.
Clinical significance of measuring the blood concentration of itraconazole oral solution in the field of hematology.
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测定伊曲康唑口服溶液血药浓度在血液学领域的临床意义
DOI：
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发表时间：
2010
影响因子：
2
通讯作者：
S. Ohta
中科院分区：
文献类型：
--
作者：
S. Shimoeda;S. Nakagawa;Hikaru Kobayashi;S. Yamato;K. Kawano;S. Ohta
一些研究表明，伊曲康唑口服液（ITCZ-OS）的预防性治疗显着降低了侵袭性真菌感染的发生率，而另一些研究则强调没有显着降低。另一方面，一项涉及中性粒细胞减少症患者的研究显示，伊曲康唑 (ITCZ) 的血液浓度增加了 15 倍。因此，与常规剂型相比，ITCZ-OS在消化道吸收更快，因此，当给血液病患者服用ITCZ-OS时，应测量ITCZ的血药浓度，以维持其有效性和安全性。为了促进ITCZ-OS的合理使用，我们进行了血药浓度监测，并探讨其临床意义。研究对象为26名血液病患者。使用HPLC测量ITCZ的血液水平。 ITCZ 的平均血液水平为 2396.5±1742.7 ng/ml（平均值±标准差）。羟基-ITCZ的平均血液水平为5384.4±3348.2ng/ml。剂量与单位体重的ITCZ/羟基-ITCZ血液水平不相关(R(2)=0.134、0.154，p=0.094、0.071)。此外，女性中单位体重的 ITCZ 和羟基-ITCZ 血液水平显着较高（p=0.025、0.010）。在男性中，肌酐清除率与单位体重的ITCZ血液水平之间存在相关性（R(2)=0.319，p=0.044）。不同患者的 ITCZ 血液水平存在差异。此外，当ITCZ-OS以200mg（ITCZ）每日剂量给药时，ITCZ的血液水平超过了该药物对疑似真菌感染的发热性中性粒细胞减少症患者可能有效的谷值。
Some studies indicated that preventive therapy with Itraconazole oral solution (ITCZ-OS) significantly decreased the incidence of invasive fungal infection, whereas others emphasized that there was no significant decrease. On the other hand, a study involving patients with neutropenia showed a 15-fold increase in the blood concentration of Itraconazole (ITCZ). Therefore, when administering ITCZ-OS, which is more rapidly absorbed in the digestive tract compared to its conventional dosage forms, to patients with blood disease, the blood concentration of ITCZ should be measured to maintain its efficacy and safety. To promote the appropriate use of ITCZ-OS, we conducted blood drug concentration monitoring, and investigated its clinical significance. The subjects were 26 patients with blood diseases. The blood level of ITCZ was measured using HPLC. The mean blood level of ITCZ was 2396.5±1742.7 ng/ml (mean±S.D.). The mean blood level of hydroxy-ITCZ was 5384.4±3348.2 ng/ml. The dose was not correlated with the blood levels of ITCZ/hydroxy-ITCZ per body weight (R(2)=0.134, 0.154, p=0.094, 0.071). Furthermore, the blood levels of ITCZ and hydroxy-ITCZ per body weight were significantly higher in females (p=0.025, 0.010). In males, there was a correlation between the creatinine clearance and blood level of ITCZ per body weight (R(2)=0.319, p=0.044). The blood levels of ITCZ varied among the patients. In addition, when ITCZ-OS was administered at a daily dose of 200 mg (ITCZ), the blood levels of ITCZ exceeded a trough level at which this agent may be effective in patients with febrile neutropenia in whom fungal infection is suspected.
影响因子：
11.8
作者：
van Burik, JAH;Ratanatharathorn, V;Walsh, TJ
通讯作者：
Walsh, TJ
影响因子：
158.5
作者：
Gallin, JI;Alling, DW;Holland, SM
通讯作者：
Holland, SM
影响因子：
20.3
作者：
Marr, KA;Crippa, F;Corey, L
通讯作者：
Corey, L