Epidemic meningococcal disease: synthesis of a hypothetical immunoepidemiologic model.
Epidemic meningococcal disease: synthesis of a hypothetical immunoepidemiologic model.
复制标题
流行性脑膜炎球菌病：假设免疫流行病学模型的综合。
DOI：
10.1093/clinids/4.1.159
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Griffiss,JM
中科院分区：
文献类型：
--
作者：
Griffiss,JM
本文提出了脑膜炎奈瑟氏菌流行行为的假设模型，该模型基于循环中的IgA诱导对播散性疾病的易感性。该模型基于这样的假设，即流行病易感性是由于肠道细菌(启动机体)的交叉反应诱导血清IgA诱导而获得的。与适当的n.菌株共生。脑膜炎可能会导致播散性疾病。在没有其他细菌的情况下，任何一种细菌的定居都会导致共生关系的加强。启动有机体缓慢、安静的粪便-口腔传播决定了流行病的时间/空间特征；粪便-口腔传播的中断使其流产。脑膜炎球菌的气溶胶传播决定了疫情的严重程度。在没有异常高水平的共同特异性血清IgA的情况下，独立的、与年龄相关的获取囊膜多糖和脂多糖抗体可提供免疫力。
A hypothetical model of the epidemic behavior ofNeisseria meningitidis, based upon the induction of susceptibility to disseminated disease by circulating IgA, is presented. The model is based on the assumption that epidemic susceptibility is acquired as a result of induction of serum IgA by cross-reacting enteric bacteria, the priming organism. Co-colonization with the appropriate strain ofN. meningitidisthen may result in disseminated disease. Colonization by either bacterium in the absence of the other results in reinforcement of the commensal relationship. Slow, silent, fecal-oral transmission of the priming organism determines the time/space characteristics of an epidemic; interruption of fecal-oral transmission aborts it. Aerosol transmission of the meningococcus determines the magnitude of an epidemic. Independent, age-related acquisition of both capsular polysaccharide and lipopolysaccharide antibodies provides immunity in the absence of aberrantly high levels of co-specific serum IgA.