Corticothalamic feedback controls sleep spindle duration in vivo.
Corticothalamic feedback controls sleep spindle duration in vivo.
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DOI：
10.1523/jneurosci.0077-11.2011
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发表时间：
2011-06-22
期刊：
影响因子：
--
通讯作者：
Bazhenov M
中科院分区：
文献类型：
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作者：
Bonjean M;Baker T;Lemieux M;Timofeev I;Sejnowski T;Bazhenov M
纺锤波振荡通常在非REM睡眠的第二阶段观察到。在睡眠纺锤波期间，大脑皮层和丘脑通过反馈连接相互作用。基于丘脑记录和计算模型，纺锤波振荡的起始和终止都被认为起源于丘脑，尽管一些体内结果表明并非如此。在这里，我们已经使用计算机建模和在体多位点记录从皮质和丘脑在猫研究的皮质参与纺锤波振荡。我们发现，虽然纺锤体的传播依赖于丘脑内的突触相互作用，纺锤体序列的启动和终止关键涉及皮质丘脑的影响。
Spindle oscillations are commonly observed during stage two of non-REM sleep. During sleep spindles, the cerebral cortex and thalamus interact through feedback connections. Both initiation and termination of spindle oscillations are thought to originate in the thalamus, based on thalamic recordings and computational models, although some in vivo results suggest otherwise. Here, we have used computer modeling and in vivo multisite recordings from the cortex and the thalamus in cats to examine the involvement of the cortex in spindle oscillations. We found that although the propagation of spindles depended on synaptic interaction within the thalamus, the initiation and termination of spindle sequences critically involved corticothalamic influences.