Control of the basement membrane and cell migration by ADAMTS proteinases: Lessons from C. elegans genetics.
Control of the basement membrane and cell migration by ADAMTS proteinases: Lessons from C. elegans genetics.
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DOI：
10.1016/j.matbio.2015.01.001
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发表时间：
2015-05
期刊：
影响因子：
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通讯作者：
Hon‐Song Kim;K. Nishiwaki
中科院分区：
文献类型：
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作者：
Hon‐Song Kim;K. Nishiwaki
ADAMTS（一种具有血小板反应蛋白基序的去整合素和金属蛋白酶）分泌蛋白家族的成员，GON-17和GON-1，在秀丽隐杆线虫性腺发生中起重要作用。这些蛋白酶的遗传和分子分析揭示了新的分子相互作用调节的基底膜（BM）在迁移的性腺前导细胞。定位于性腺BM的β-17募集或激活纤蛋白-1和IV型胶原蛋白，其然后募集巢蛋白，从而诱导引导细胞迁移的定向控制所需的BM重塑。GON-1与fibulin-1起拮抗作用，以调节性腺BM中IV型胶原积累的水平，这促进了前导细胞的主动迁移。ADAMTS-17和GON-1的协同作用为了解ADAMTS蛋白酶介导的器官发生机制提供了一个很好的模型。
The members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of secreted proteins, MIG-17 and GON-1, play essential roles inCaenorhabditis elegansgonadogenesis. The genetic and molecular analyses of these proteinases uncovered novel molecular interactions regulating the basement membrane (BM) during the migration of the gonadal leader cells. MIG-17, which is localized to the gonadal BM recruits or activates fibulin-1 and type IV collagen, which then recruits nidogen, thereby inducing the remodeling of the BM that is required for directional control of leader cell migration. GON-1 acts antagonistically with fibulin-1 to regulate the levels of type IV collagen accumulation in the gonadal BM, which facilitates active migration of the leader cells. The cooperative action of MIG-17 and GON-1 represents an excellent model for understanding the mechanisms of organogenesis mediated by ADAMTS proteinases.